Endothelial Defense™ Pomegranate Plus

Category: Blood vessels


For healthy arteries, protect your vascular endothelium

  • Promotes arterial and circulatory health

  • Helps inhibit vascular inflammation

  • Supports healthy endothelial cell function

  • Helps protect your veins from oxidative stress

  • Promotes vascular dilation and circulation

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Endothelial Defense™ Pomegranate Complete Plus

60 softgels

Item Catalog Number: 02497

NON GMO Product

Life Extension’s unique Endothelial Defense™ Pomegranate Complete Plus formula combines pomegranate fruit extracts and seed oil, Extramel® melon pulp concentrate, and Cardiose® sweet orange peel extract: three powerful ingredients that have been shown to help protect the delicate cells that line the inside of your blood vessels.

Benefits at a Glance:

  • Promotes arterial and circulatory health

  • Helps inhibit vascular inflammation

  • Supports healthy endothelial cell function

  • Helps protect your veins from oxidative stress

  • Promotes vascular dilation and circulation

More facts about Endothelial Defense™ Pomegranate Complete Plus

Blood vessels are lined with a delicate layer of cells known as the endothelium. This endothelial layer is responsible for regulating the health and function of arteries and veins. As you age, protecting the endothelium is critical for maintaining vascular health.

Pomegranate Complete is a potent source of unique polyphenol extracts from every part of the pomegranate, including the seed, flower, and fruit. Pomegranate extracts have valuable health benefits, including promoting healthy endothelial function; inhibiting oxidative stress; supporting metabolic and cardiovascular health; and encouraging a healthy inflammatory response.1-11

® extract from sweet orange peel helps promote endothelial production of nitric oxide,13 which encourages vasodilation — a key requirement for healthy circulation.

Clinically studied orange peel extract

In a randomized controlled trial, 500 mg of sweet orange peel extract produced an 20% improvement in flow-mediated dilation, a direct marker of healthy endothelial function.14 This extract also promoted a normal, healthy inflammatory response.15

Melon concentrate promotes antioxidant production

Extramel® is a concentrate of a special variety of a French melon. It encourages the body to produce superoxide dismutase (SOD), a potent inhibitor of oxidative stress.12,13 In pre-clinical models, consuming Extramel® melon concentrate increased SOD levels in various organ tissues.14

Extramel® appears to support overall quality of life as well. In not one, but two studies, subjects consuming 10 mg a day of this melon concentrate reported decreased feelings of general fatigue. Healthy stress response and increased feelings of well-being were reported as well.15,16

If you’re ready to give your cardiovascular health a boost of targeted nutritional support, add Endothelial Defense™ Pomegranate Complete Plus to your daily regimen.

Supplement Facts

Serving Size 2 softgels

Servings Per Container 30

Amount Per Serving
Calories 20
Total Fat 1.5 g
Total Carbohydrate 1 g
Protein <1 g
Cardiose® flavonoid glycoside [from immature sweet orange (peel)] [std. to 90% rutinoside] 500 mg
POMELLA® pomegranate extract (fruit) [std. to 30% punicalagins] 400 mg
Proprietary pomegranate blend (flower extract and seed oil) [std. to 22% punicic acid] 137.5 mg
Pomegranate 5:1 extract (fruit) 100 mg
Extramel® melon pulp concentrate (fruit) [providing 500 IU of SOD enzyme activity] 36 mg
Other ingredients: extra virgin olive oil, gelatin, glycerin, sunflower lecithin, purified water, beeswax, carob color, dextrin.


Cardiose® is a registered trademark of INTERQUIM, S.A. d.b.a. Ferrer HealthTech.

POMELLA® Extract is covered under U.S. Patent 7,638,640 and POMELLA® is a registered trademark of Verdure Sciences, Inc.

Extramel® is a registered trademark of Bionov.

Dosage and Use

Take two (2) softgels daily before breakfast, or as recommended by a healthcare practitioner.




Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Mol Nutr Food Res. 2017 May;61(5)

  2. Phytother Res. 2017 Nov;31(11):1731-1738.

  3. J Sci Food Agric. 2017 Apr;97(6):1798-1804.

  4. Complement Ther Clin Pract. 2016 Feb;22:44-50.

  5. J Med Food. 2015 Sep;18(9):941-9.

  6. Plant Foods Hum Nutr. 2015 Mar;70(1):9-14.

  7. Plant Foods Hum Nutr. 2012 Dec;67(4):351-7.

  8. Plant Foods Hum Nutr. 2012 Sep;67(3):309-14.

  9. Front Pharmacol. 2018;9:544.

  10. J Nutr Sci. 2012;1:e9.

  11. J Nutr Sci. 2017;6:e39.

  12. Eur Ann Allergy Clin Immunol. 2007 Feb;39(2):45-50.

  13. Agro Food Industry Hi Tech. 2015 July/August 2015;26(4):6-10.

  14. American Journal of Physiology - Heart and Circulatory Physiology. 2002;282(1):H1-H5.

  15. www.cordiart.com. Accessed Oct 12, 2018.

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