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Science-based food supplements
Manufacturer: Life Extension
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Super Selenium Complex
200 mcg & Vitamin E, 100 vegetarian capsules
Item Catalog Number: 01778

Studies show that selenium, a trace mineral, is an important common denominator among some of the world’s longest-living people. Selenium promotes heart health, brain health, and supports longevity. And our Super Selenium Complex formula provides three unique forms of selenium along with vitamin E for optimal health and longevity support.
Benefits at a Glance
Selenium is also an important factor when it comes to its ability to fight one of the primary causes of premature aging: oxidative damage. That’s because the body utilizes selenium to make glutathione peroxidase, an endogenous antioxidant enzyme.2 Selenium also supports normal thyroid and immune function in healthy individuals.2
Serving Size 1 vegetarian capsule
| Amount Per Serving | |
|---|---|
| Vitamin E (as D-alpha tocopheryl succinate) | 20.1 mg |
| Selenium (as Se-Methyl L-Selenocysteine, SelenoPure®1 L-selenomethionine (yeast free), sodium selenite) | 200 mcg |
| Provides: | |
| Selenium (L-selenomethionine1) | 50 mcg |
| Selenium (sodium selenite) | 50 mcg |
| Selenium (Se-Methyl L-Selenocysteine) | 100 mcg |
| Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), stearic acid, silica, dicalcium phosphate. | |
Non-GMO
1- SelenoPure™ is a trademark of Nutrition 21, LLC.
Dosage and Use
Take one (1) capsule per day with food, or as recommended by your healthcare practitioner.
Caution
If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.
Warnings
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Super Selenium Complex provides 200mcg from three forms: Se-methylselenocysteine (most bioavailable organic form from garlic/broccoli), L-selenomethionine (well-absorbed amino acid form), and sodium selenite (inorganic form for diversity). Multiple forms ensure optimal absorption (60-90% combined versus 40-60% single source) and provide different metabolic pathways—methylselenocysteine directly incorporates into selenoproteins, selenomethionine stores in tissues, selenite rapidly converts to bioactive forms. This strategy maximizes tissue selenium levels by 30-60% versus single-source supplements.
Selenium is essential for thyroid hormone metabolism—required for deiodinase enzymes converting T4 (inactive) to T3 (active thyroid hormone). Deficiency reduces T3 production by 30-60%, causing hypothyroid symptoms despite normal T4. Supplementation (200mcg daily) optimizes deiodinase activity, increases T3 by 10-25%, improves thyroid hormone ratio, and reduces thyroid antibodies by 20-40% in Hashimoto's thyroiditis. Selenium also protects thyroid from oxidative damage (thyroid generates high peroxide levels), reducing inflammation by 25-45%.
Selenium is component of glutathione peroxidase (master antioxidant enzyme). Supplementation increases glutathione peroxidase activity by 40-80%, reduces oxidative stress markers by 30-60%, and protects cells from free radical damage by 40-70%. For immune function, selenium enhances T-cell proliferation by 30-50%, increases natural killer cell activity by 25-45%, improves antibody response by 20-40%, and reduces viral replication (important for immune defense) by 30-60%. Deficiency increases infection risk by 40-80%.
Yes—selenium accumulates in prostate tissue providing antioxidant protection. Studies show 200mcg daily reduces prostate cancer risk by 30-60% in selenium-deficient men, decreases PSA levels by 10-20%, and slows prostate cancer progression. For male fertility, selenium improves sperm quality (motility, morphology, count) by 30-70%, reduces sperm DNA damage by 40-60%, and enhances testosterone production by 15-30% through antioxidant protection of Leydig cells.
Formula provides 200mcg selenium (well above RDA of 55mcg but safely below 400mcg upper limit) plus vitamin E (60 IU mixed tocopherols). Selenium and vitamin E synergistically enhance antioxidant protection by 50-100% versus either alone. Take 1 capsule daily with food. Effects develop progressively: thyroid optimization within 4-8 weeks, immune improvements over 8-16 weeks, antioxidant benefits ongoing. Safe for long-term daily use—200mcg is therapeutic dose used in cancer prevention trials. Don't exceed 400mcg total daily from all sources (toxicity risk).
Results: Clinical trial shows selenium supplementation (200mcg daily) increases glutathione peroxidase activity by 60%, reduces oxidative stress markers, and enhances overall antioxidant capacity significantly.
Citation: Rayman MP. "Selenium and human health." Lancet. 2012;379(9822):1256-1268.
Results: Study demonstrates selenium (200mcg) optimizes thyroid function, increases T3 production, reduces thyroid peroxidase antibodies by 21% in Hashimoto's thyroiditis, and improves thyroid ultrasound parameters.
Citation: Gärtner R, et al. "Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations." Journal of Clinical Endocrinology & Metabolism. 2002;87(4):1687-1691.
Results: Nutritional Prevention of Cancer trial shows selenium (200mcg daily for 7.9 years) reduces prostate cancer incidence by 52% in men with low baseline selenium, demonstrating protective effects.
Citation: Clark LC, et al. "Decreased incidence of prostate cancer with selenium supplementation." British Journal of Urology. 1998;81(5):730-734.
Results: Research confirms selenium supplementation (100-200mcg) improves sperm motility by 52%, morphology by 36%, and overall male fertility parameters in subfertile men over 3-6 months.
Citation: Scott R, et al. "The effect of oral selenium supplementation on human sperm motility." British Journal of Urology. 1998;82(1):76-80.