Senolytic Activator

Category: Anti-aging


Combat cellular senescence

  • Helps the body manage senescent cells
  • Promotes youthful, healthy cellular function
  • Supports systemic rejuvenation
  • Innovative formula made with black tea theaflavins, highly absorbable quercetin, apigenin and fisetin
  • Convenient once-a-week dosing

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Senolytic Activator

Item Catalog Number: 02301

36 vegetarian capsules

NON GMO Product

Cellular senescence is a natural part of the aging process in which cells no longer function optimally. Senescent cells can accumulate over time, affecting the day-to-day function of the healthy cells around them. Senolytic compounds selectively target senescent cells.

Black tea theaflavins, quercetin and apigenin target specific biological pathways, helping to manage senescent cells.

Benefits at a glance:

  • Helps the body manage senescent cells
  • Promotes youthful, healthy cellular function
  • Supports systemic rejuvenation
  • Innovative formula made with black tea theaflavins, highly absorbable quercetin, apigenin and fisetin
  • Convenient once-a-week dosing

New research indicates that black tea theaflavins and quercetin target specific biological pathways, making it easier for the body to manage senescent cells.2-4

Theaflavins reduce senescent cell burden

Theaflavins are compounds derived from Camellia sinensis (tea plant). These compounds have widespread health benefits, supporting healthy cell division and healthy inflammatory response.5,6

New research indicates that theaflavins may be especially helpful for reducing senescent cell burden. In pre-clinical models, theaflavins helped powerfully inhibit the accumulation of particular cell senescence biomarkers.2

Quercetin promotes cellular health and more

Quercetin supports endothelial and cardiovascular health, promotes healthy immune function and more.7,8 The value of quercetin has been recognized for some time. But its potential to meaningfully impact whole body rejuvenation is just starting to be uncovered through its senolytic activity. The discovery that quercetin is a senolytic compound has drawn significant attention to this innovative approach to combat aging.4

Better absorption than standard types of quercetin

Standard quercetin is hard to absorb. But this formulation features our new quercetin phytosome, a phospholipid sphere that encases the quercetin, aiding in its absorption and making it up to 50 times more bioavailable.

Easy-to-absorb fisetin to boost longevity at the cellular level

Fisetin is terrific for whole-body health. It’s a powerful senolytic compound, meaning it actively target senescent cells, the ones that no longer function optimally. Fisetin helps encourage the body’s natural pathways for clearing senescent cells, which allows healthy cells to flourish.9

Another important aspect of cellular longevity is sirtuin function. Sirtuin proteins keep your cells performing at their best—but sirtuin activity declines with age.10 Fisetin has been shown in preclinical studies to encourage youthful, healthy sirtuin function.11-15

But during digestion, much of fisetin is rapidly converted into other compounds by a process called conjugation. That’s why we protected fisetin by combining it with galactomannans, a type of fiber derived from fenugreek seed. Doing so makes it up to 25 times more readily available than standard fisetin.16 That means it circulates in your system longer and your body has more time to access fisetin’s many health benefits.


Life Extension has identified apigenin, a natural flavonoid, as a powerful addition to our Senolytic Activator formula. Quercetin and theaflavins from black tea target senescent cells, but not all of them.

The remaining senescent cells create compounds known collectively as Senescence Associated Secretory Phenotype, or SASP.9 Apigenin helps inhibit remaining senescent cells from making SASP to support cellular and tissue health—a critical aspect of healthy aging.10

Convenient, once-weekly formula

For those who aren’t keen on adding another supplement to their regimen, here’s good news: Senolytic research indicates that intermittent dosing in pre-clinical studies is effective at improving healthspan.4 So, Senolytic Activator instructions call for taking just three vegetarian capsules, once a week.

Manage senescent cells, promote healthy cellular function and support overall longevity with Senolytic Activator.

Supplement Facts

Serving Size 3 vegetarian capsules
Servings Per Container 12

Amount Per Serving
Bio-Fisetin Proprietary Blend
Providing 18% fisetin (56 mg) [from wax tree extract (stem)], 35% galactomannans (109 mg) [from fenugreek (seed)]
312 mg
Theaflavins [from decaffeinated black tea extract (leaf)] 275 mg

Bio-Quercetin phytosome 25 mg quercetin [from Japanese sophora concentrate (flower bud)], phosphatidylcholine complex [from sunflower])

74 mg


50 mg

Other ingredients: vegetable cellulose (capsule), sunflower lecithin, microcrystalline cellulose, silica, vegetable stearate.


Dosage and Use
Take three (3) capsules once weekly, with or without food, or as recommended by a healthcare practitioner.


  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Exp Gerontol. 2015;68:19-25
  2. Free Radic Biol Med. 2017;113:59-70.
  3. Pharmacol Res. 2012;66(4):363-73.
  4. Aging Cell. 2015;14(4):644-58.
  5. Oxid Med Cell Longev. 2009;2(5):270-8.
  6. Cardiovasc Res. 2007;73(2):348-58.
  7. Nutrients. 2016;8(3):167.
  8. Trends in Food Science & Technology. 2016;56:21-38.
  9. Nat Med. 2015;21(12):1424-35.
  10. Biochem Pharmacol. 2015;96(4):337-48.

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