TAXIFOLIN Dihydroquercetin

Category: Antioxidants

Manufacturer:

Strong antioxidant and anti-inflammatory properties

  • Inhibits inflammation and oxidative stress
  • Supports the circulatory system and endothelial health
  • Supports liver health
  • Supports the body's fight against seasonal infections
  • Supports bone health
  • Suitable for vegetarians due to Vcaps® capsule

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TAXIFOLIN Dihydroquercetin

60 capsules

Item Catalog Number: K0680EN

Original product name: TAXIFOLIN Dihydrokwercetyna

Taxifolin (dihydroquercetin) is a molecular variant of the flavonoid quercetin, but much better absorbed than traditional quercetin. Taxifolin is a flavonoid compound found in food such as onions and olive oil, larch, camphor pine and water safflower.[1,3]

Benefits at a Glance:

  • Inhibits inflammation and oxidative stress
  • Supports the circulatory system and endothelial health
  • Supports liver health
  • Supports the body's fight against seasonal infections
  • Supports bone health
  • Suitable for vegetarians due to Vcaps® capsule

Taxifolin as an antioxidant

The chemical structure of Taxifolin allows it to fight free radicals much more effectively than other flavonoids.[1,2]

Some research shows that taxifolin could be used to treat allergic and inflammatory conditions due to its anti-inflammatory properties.[1]

Taxifolin and cardiovascular health

Taxifolin may be helpful in the prevention and treatment of cardiovascular disease. It protects the cardiovascular system by protecting the integrity of the endothelium of blood vessels.

In porcine coronary artery rings studies, showed Taxifolin's vasorelaxant effect.[4]

Taxifolin helps maintain the healthy lipid profile of the liver and lipid excretion at optimal levels. Taxifolin prevents hyperlipidemia by reducing the esterification of cellular cholesterol, phospholipid, and triacylglycerol synthesis.[1]

Taxifolin and liver health

Taxifolin reverses acute alcohol-induced liver injury by alleviating oxidative stress injury. One of new study, for the first time shows, that Taxifolin can reduce alcoholic liver toxicity.[11]
By regulating the glutathione pathway, Taxifolin protects also against paracetamol-induced liver injury.[12]

Taxifolin, seasonal infections and respiratory health

There is growing evidence that taxifolin plays very important role in respiratory disease. Taxifolin shows as an effective treatment for acute lung injury. It inhibits inflammation caused by acute lung injury.[1,7]

Taxifolin has also been shown to encourage a healthy immune response, especially to seasonally changing environments.

Taxifolin and bone health


The balance of bones is maintained by the interaction of osteoclast bone resorption and osteoblastic osteogenesis. Due to its anti-inflammatory properties, taxifolin plays important role in the regulation and balance of bone metabolism. Moreover, taxifolin alleviated bone loss caused by oophorectomy.[1,8]

In another in vitro study, taxifolin inhibited RANKL*-induced osteoclast differentiation in human bone marrow-derived macrophages (BMMs) without cytotoxicity. In a mouse calvarial osteolysis model in vivo, taxifolin also prevented bone loss as assessed.[1,9,10] 

*RANKL (Receptor Activator for Nuclear Factor κ B Ligand - a protein involved in bone metabolism {osteoclast activation}, belonging to the family of tumor necrosis factors.)

Supplement Facts

Daily dose: 2 capsules

Amount Per Day (2 capsules)

Taxifolin 92% (dihydroquercetin)

100 mg

Ingredients: bulking agent: microcrystalline cellulose, taxifolin(dihydroquercetin), capsule shell: hydroxypropyl methylcellulose.


Vcaps® is a trademark of Lonza or its affiliates.



Dosage and Use

Take one (1) capsule two (2) times daily or as directed by your healthcare professional.

Warnings:

Before you start using any dietary supplement, consult your doctor. 

Dietary supplements are not medicines.

Do not exceed the recommended daily dose.

Dietary supplements cannot be used as a substitute for a varied diet.

Do not use in case of hypersensitivity to any ingredient of the preparation.

The product should not be used by pregnant or breastfeeding women and children and adolescents under 18 years of age.

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227600/
  2. Zu Y., Wu W., Zhao X., Li Y., Wang W., Zhong C., et al. (2014). Enhancement of solubility, antioxidant ability and bioavailability of taxifolin nanoparticles by liquid antisolvent precipitation technique. Int. J. Pharm. 471, 366–376. 10.1016/j.ijpharm.2014.05.049
  3. Liu Z., Jia J., Chen F., Yang F., Zu Y., Yang L. (2014). Development of an ionic liquid-based microwave-assisted method for the extraction and determination of taxifolin in different parts of Larix gmelinii. Molecules 19, 19471–19490. 10.3390/molecules191219471
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979019/
  5. Das A., Baidya R., Chakraborty T., Samanta A.K., Roy S. Pharmacological basis and new insights of taxifolin: A comprehensive review. Biomed. Pharmacother. 2021;142:112004. doi: 10.1016/j.biopha.2021.112004.
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865844/
  7. Jh L., Liango C., Ch Z., Chen L., Zh Z. (2020). Dihydroquercetin attenuates lipopolysaccharide-induced acute lung injury through modulating FOXO3-mediated NF-κB signaling via miR-132-3p. Pulm. Pharmacol. Ther. 64, 101934.
  8. Satué M., Arriero M., del M., Monjo M., Ramis J. M. (2013). Quercitrin and taxifolin stimulate osteoblast differentiation in MC3T3-E1 cells and inhibit osteoclastogenesis in RAW 264.7 cells. Biochem. Pharmacol. 86, 1476–1486. 10.1016/j.bcp.2013.09.009
  9. Cai C., Liu C., Zhao L., Liu H., Li W., Guan H., et al. (2018). Effects of taxifolin on osteoclastogenesis in vitro and in vivo . Front. Pharmacol. 9, 1286. 10.3389/fphar.2018.01286
  10. Zhang H.-Q., Wang Y.-J., Yang G.-T., Gao Q.-L., Tang M.-X. (2019b). Taxifolin inhibits receptor activator of NF-κB ligand-induced osteoclastogenesis of human bone marrow-derived macrophages in vitro and prevents lipopolysaccharide-induced bone loss in vivo . Pharmacology 103, 101–109. 10.1159/000495254
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259856/
  12. https://pubmed.ncbi.nlm.nih.gov/31593705/

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