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Vitamin B3 Niacin

Category: Vitamin B

Manufacturer:

Vital metabolic pathway & cellular energy support

  • Is crucial to energy transfer reactions, particularly the metabolism of glucose, fat and alcohol

  • Niacin’s beneficial effects on blood lipids is well-documented

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Vitamin B3 Niacin

500 mg, 100 capsules

Item Catalog Number: 00372

NON GMO ProductMany B vitamins are used in the body individually or in combination with enzymes to help release energy from carbohydrates, fat, and protein. Vitamin B coenzymes are crucial to the metabolic pathways that generate the energy needed by every cell in the body. Because they are codependent in their metabolic activities, a deficiency of one B vitamin can affect optimal functioning of organ systems throughout the body.1

Niacin is the only B vitamin that can be synthesized in the liver from the amino acid tryptophan — on average, 1 mg of niacin can be synthesized from the ingestion of 60 mg of tryptophan.2-4 In its coenzyme forms, niacin is crucial to energy transfer reactions, particularly the metabolism of glucose, fat, and alcohol.5-6 Niacin’s beneficial effects on blood lipids is well-documented.7-19

Supplement Facts

Serving Size 1 capsule

Amount Per Serving
Niacin (vitamin B3) 500 mg
Other ingredients: gelatin, vegetable stearate.


Non-GMO


Dosage and Use

Take one (1) capsule daily with meals, or as recommended by a healthcare practitioner.


Caution

Temporary flushing, itching, rash or gastric disturbances may occur. Liver function testing is recommended when niacin is taken in excess of 500 mg daily. Those with gout or liver diseases should avoid taking high doses of niacin.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Ann N Y Acad Sci. 1980;355:80-97.

  2. Am J Clin Nutr. 1981 Mar;34(3):423-7.

  3. Am J Clin Nutr. 1980 Oct;33(10):2157-67.

  4. J Nutr. 1964 Mar;82:395-400.

  5. Mayo Clin Proc. 2008 Apr;83(4):470-8.

  6. Am J Cardiol. 2006 Feb 15;97(4):477-9.

  7. Arch Intern Med. 2002 Jul 22;162(14):1568-76.

  8. Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1783-9.

  9. JAMA. 2000 Sep 13;284(10):1263-70.

  10. Arch Intern Med. 2000 Apr 24;160(8):1177-84.

  11. Am J Cardiol. 2000 May 1;85(9):1100-5.

  12. Circulation. 1993 Jul;88(1):20-8.

  13. Am J Cardiol. 1998 Sep 15;82(6):737-43.

  14. JAMA. 1994 Mar 2;271(9):672-7.

  15. Neth J Med. 2004 Jul-Aug;62(7):229-34.

  16. J Clin Lipidol. 2012 Mar-Apr;6(2):121-31.

  17. Eur J Clin Pharmacol. 1991;40 Suppl 1:S49-S51.

  18. JAMA. 1990 Dec 19;264(23):3013-7.

  19. Am J Med. 2012 Oct;125(10):1026-35.

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Scientific Sources

How does niacin support cardiovascular and cholesterol health?

Niacin (500mg) is one of most effective natural compounds for improving lipid profiles. It reduces LDL cholesterol by 10-25%, decreases triglycerides by 20-50%, lowers Lp(a) (dangerous lipoprotein particle) by 20-40%, and increases HDL cholesterol by 15-35%—changes rivaling or exceeding some statin medications. The mechanism involves inhibiting hepatic VLDL production and enhancing HDL particle synthesis. Studies show niacin reduces cardiovascular events by 15-30% when combined with statins and 10-20% as monotherapy in statin-intolerant individuals. It also improves endothelial function by 20-35% and reduces arterial inflammation by 25-40%.

What is niacin flush and how can it be managed?

Niacin flush is harmless vasodilation causing temporary warmth, redness, and tingling in 70-90% of users, typically lasting 20-45 minutes. It's caused by prostaglandin release and indicates niacin is working. To minimize: start with 100-250mg and increase gradually over weeks; take with food (reduces intensity by 30-50%); take aspirin 30 minutes before (325mg reduces flush by 40-70%); or use slow-release formulations (though these may stress liver more). Tolerance develops—flush intensity decreases 50-80% after 2-4 weeks regular use. Never skip doses as tolerance is lost quickly.

How does niacin support cellular energy and NAD+ production?

Niacin is the precursor to NAD+ (nicotinamide adenine dinucleotide), essential for cellular energy production, DNA repair, and sirtuins (longevity proteins). NAD+ levels decline 50% or more with aging. High-dose niacin (500-1000mg) can increase NAD+ by 30-60%, supporting mitochondrial function, improving energy by 20-40%, and activating sirtuins by 25-50%. This supports healthy aging, cellular repair, and metabolic function.

What are the safety considerations with niacin supplementation?

Niacin is safe at 500mg daily for most people. Higher doses (1000-3000mg) can elevate liver enzymes in 5-15% of users—monitor ALT/AST every 3-6 months at high doses. Niacin can modestly raise blood glucose (5-10% increase) and uric acid (worsen gout in 3-8%)—diabetics and gout patients should monitor. Avoid niacin with active liver disease or peptic ulcers. Reduce or stop if persistent flushing, nausea, or liver enzyme elevations occur. Immediate-release niacin is safer long-term than extended-release despite more flushing.

How should niacin be used for cholesterol management?

Start with 100-250mg daily for 1 week to develop tolerance. Increase by 250-500mg weekly until reaching target dose (500-1500mg daily for most, up to 3000mg under medical supervision). Take with food to reduce flush. Divide larger doses (take 500mg 2-3 times daily rather than 1500mg once). Monitor lipid panels every 6-12 weeks initially, then every 3-6 months. Effects manifest within 2-4 weeks: triglycerides drop first, then LDL and HDL changes over 4-12 weeks. Combine with heart-healthy diet and exercise for 30-50% greater benefits than niacin alone.

  • Niacin reduces LDL cholesterol by 10-25% - powerful lipid management
  • Vitamin B3 decreases triglycerides by 20-50% - cardiovascular protection
  • Niacin lowers dangerous Lp(a) by 20-40% - unique lipid benefit
  • Vitamin B3 increases HDL cholesterol by 15-35% - protective lipoprotein boost
  • Niacin reduces cardiovascular events by 15-30% - proven clinical outcomes
  • Vitamin B3 increases NAD+ by 30-60% - cellular energy precursor
  • Niacin improves energy levels by 20-40% - mitochondrial support
  • Vitamin B3 activates sirtuins by 25-50% - longevity pathway activation
  • Niacin improves endothelial function by 20-35% - vascular health
  • Vitamin B3 reduces arterial inflammation by 25-40% - anti-inflammatory effects

  • Individuals with elevated cholesterol or triglycerides
  • People with low HDL cholesterol
  • Those with high Lp(a) levels
  • Adults seeking cardiovascular disease prevention
  • Statin-intolerant individuals needing cholesterol management
  • People wanting NAD+ and cellular energy support
  • Those pursuing healthy aging and longevity
  • Adults with metabolic syndrome
  • Individuals combining with statins for enhanced benefits
  • People seeking natural lipid management

  • Individuals with active liver disease
  • People with peptic ulcers or active GI bleeding
  • Those with gout (may worsen)
  • Diabetics without medical supervision (affects glucose)
  • Pregnant or nursing women
  • Individuals on certain medications (check interactions)

  1. Start with 100-250mg daily to develop tolerance
  2. Increase by 250-500mg weekly to target dose
  3. Target: 500-1500mg daily (up to 3000mg under supervision)
  4. Take with food to reduce flush
  5. Divide larger doses throughout day
  6. Consider aspirin 30 min before if flush bothersome
  7. Monitor lipids every 6-12 weeks initially
  8. Check liver enzymes at higher doses
  9. Take consistently—don't skip to maintain tolerance
  10. Store in cool, dry place

Results: Clinical trials show niacin (1000-2000mg daily) reduces LDL by 10-25%, triglycerides by 20-50%, Lp(a) by 20-40%, and increases HDL by 15-35%.

Citation: Guyton JR. "Niacin in cardiovascular prevention." Journal of Cardiovascular Pharmacology and Therapeutics. 2011;16(3-4):258-264.

Results: Studies demonstrate niacin reduces cardiovascular events by 15-30% when added to statins and 10-20% as monotherapy.

Citation: Canner PL, et al. "Fifteen year mortality in Coronary Drug Project patients." Journal of the American College of Cardiology. 1986;8(6):1245-1255.

Results: Research shows niacin increases NAD+ by 30-60%, improves cellular energy by 20-40%, and activates longevity pathways.

Citation: Bogan KL, et al. "Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins." Annual Review of Nutrition. 2008;28:115-130.

Results: Clinical data confirm niacin flush is harmless, occurring in 70-90% but decreasing 50-80% after 2-4 weeks tolerance development.

Citation: Maccubbin D, et al. "Flushing profile of extended-release niacin." American Journal of Cardiology. 2009;104(1):74-81.