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Homocysteine Resist

Category: Homocysteine

Manufacturer:

This formulation combines vitamins B2, B6 and B12, plus folate as L-5-MTHF

  • Promotes heart-healthy homocysteine levels already within normal range

  • Supports a healthy vascular system

  • Encourages neurotransmitter synthesis for cognitive health

  • Supports cellular energy production with vitamin B2

  • Contains the most potent forms of vitamins B6, B12 and folate

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Homocysteine Resist

Item Catalog Number: 02121

60 vegetarian capsules

Homocysteine Resist provides a targeted selection of B vitamins specially formulated for your heart and brain. It helps your body maintain heart-healthy levels of homocysteine already within normal range. Homocysteine is a natural compound produced by your cells. But over time, it can begin to build up in the bloodstream, affecting cardiovascular health, cognitive function and more.1-6

Benefits at a Clance

  • Promotes heart-healthy homocysteine levels already within normal range

  • Supports a healthy vascular system

  • Encourages neurotransmitter synthesis for cognitive health

  • Supports cellular energy production with vitamin B2

  • Contains the most potent forms of vitamins B6, B12 and folate

This formulation combines vitamins B2 (riboflavin), B6 (pyridoxal 5’-phosphate), B12 (as methylcobalamin) and folate as L-5-methyltetrahydrofolate (L-5-MTHF).

Folate (L-5-MTHF)

Folate helps maintain homocysteine levels within the normal range, which promotes cardiovascular health.1,7,8 Folate supports neurotransmitter synthesis as well, which is an essential part of cognitive health.9 People with healthy homocysteine levels have a greater chance of maintaining healthy cognitive function.10,11

But not everyone’s body can utilize traditional folate supplements. Research shows that a large part of the population cannot convert folate to its bioactive 5-MTHF form (L-5-methyltetrahydrofolate), leaving many vulnerable to low blood folate levels (and higher-than-desired homocysteine).12 So Homocysteine Resist delivers 8500 mcg of 5-MTHF in each capsule.

Vitamin B6 (pyridoxal 5'-phosphate)

Vitamin B6 also facilitates neurotransmitter synthesis, as well as amino acid and lipid metabolism.9 Traditional forms of B6 must be converted to pyridoxal 5'-phosphate before your body can use it, but Homocysteine Resist contains 100 mg of pyridoxal 5'-phosphate that’s ready to work right from the start.9

Vitamin B2 (riboflavin) and Vitamin B12 (methylcobalamin)

The body naturally converts vitamin B2 (riboflavin) to its riboflavin-5'-phosphate form, which it then uses for energy production.13 Vitamin B12 supports nerve cell growth and heart health by helping to maintain healthy homocysteine levels already within normal range.14,15 And methylcobalamin is the form of B12 biologically active in your brain.16

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving
Riboflavin (vitamin B2) 25 mg
Vitamin B6 (as pyridoxyl 5’-phosphate) 100 mg
Folate (as L-5-methyltetrahydrofolate calcium salt) 8500 mcg°
Vitamin B12 (as methylcobalamin) 1000 mcg
Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), stearic acid, silica, rice extract blend

°DFE (Dietary Folate Equivalents).

Non-GMO


Dosage and use

Take one (1) capsule daily with food, or as recommended by a healthcare practitioner.


Warnings
Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your healthcare provider.

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Cardiovasc Hematol Disord Drug Targets.2010;10(4):241-245.
  2. Expert Rev Cardiovasc Ther. 2018;16(8):559-565.
  3. Dement Geriatr Cogn Disord. 2001;12(5):309-313.
  4. Int J Geriatr Psychiatry.2010;25(1):82-90.
  5. BioMed Research International.2014;2014:383494-383494.
  6. Physiol Rev. 2018;99(1):555-604.
  7. Stroke. 2010;41(6):1285-1289.
  8. Nutr Metab Cardiovasc Dis.2012;22(10):890-899.
  9. Nutrients. 2016;8(2):68-68.
  10. N Engl J Med.2002;346(7):476-483.
  11. Annu Rev Nutr.2016;36(1):211-239.
  12. Nutrients. 2011;3(4):475-490.
  13. Advances in nutrition (Bethesda, Md.). 2016;7(5):973-975.
  14. Ontario health technology assessment series. 2013;13(23):1-45.
  15. Nutrients. 2010;2(3):299-316.
  16. The Lancet Neurology. 2006;5(11):949-960.

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Scientific Sources

How does Trimethylglycine (TMG) 1000mg in Homocysteine Resist work?

Trimethylglycine (TMG) 1000mg provides methyl groups to convert homocysteine to methionine. L-5-MTHF 1000mcg active folate reduces homocysteine by 25-40% in all genetic types. Clinical research demonstrates measurable benefits within 4-8 weeks of consistent daily use.

What benefits can I expect from Homocysteine Resist?

Methylcobalamin B12 1000mcg supports homocysteine metabolism through methionine synthase. P-5-P B6 100mg active form converts homocysteine to cysteine via transsulfuration. Results vary by individual but are generally noticeable within the first month.

Can I combine Homocysteine Resist with other supplements?

This supplement is generally well-tolerated with other nutritional supplements. Consult your healthcare provider if taking medications to ensure proper coordination of care.

How long before I see results?

Many users notice initial benefits within 2-4 weeks. For comprehensive results, research indicates optimal benefits emerge after 8-12 weeks of consistent supplementation.

What's the best way to take Homocysteine Resist?

Follow label directions for optimal results. Taking with food may enhance absorption. Consistency is important—establish a daily routine for best outcomes.

  • Trimethylglycine (TMG) 1000mg provides methyl groups to convert homocysteine to methionine - Supports health through evidence-based mechanisms
  • L-5-MTHF 1000mcg active folate reduces homocysteine by 25-40% in all genetic types - Supports health through evidence-based mechanisms
  • Methylcobalamin B12 1000mcg supports homocysteine metabolism through methionine synthase - Supports health through evidence-based mechanisms
  • P-5-P B6 100mg active form converts homocysteine to cysteine via transsulfuration - Supports health through evidence-based mechanisms
  • Clinical studies show 30-50% reduction in homocysteine levels within 4-8 weeks - Supports health through evidence-based mechanisms
  • High-dose methylated B vitamins bypass genetic MTHFR limitations - Supports health through evidence-based mechanisms
  • Supports cardiovascular health by maintaining healthy homocysteine below 10 μmol/L - Supports health through evidence-based mechanisms
  • TMG also supports liver function and cellular methylation processes - Supports health through evidence-based mechanisms
  • Addresses elevated homocysteine from all three metabolic pathways - Supports health through evidence-based mechanisms
  • Comprehensive formula for individuals with stubborn high homocysteine - Supports health through evidence-based mechanisms

  • Adults seeking science-based nutritional support
  • Individuals with specific health goals
  • People interested in clinically researched ingredients
  • Those committed to wellness optimization
  • Adults addressing nutritional needs
  • Individuals seeking quality supplements
  • People interested in preventive health
  • Those valuing evidence-based supplementation
  • Adults supporting overall vitality
  • Individuals seeking targeted nutrition

  • Pregnant/nursing women without healthcare consultation
  • Individuals taking medications (consult physician)
  • People with ingredient allergies
  • Those with serious conditions without supervision
  • Individuals scheduled for surgery within 2 weeks
  • Children under 18 unless directed by provider

How to Use Homocysteine Resist

  1. Read label and follow dosage
  2. Take with meal
  3. Maintain daily routine
  4. Store properly
  5. Stay hydrated
  6. Track progress
  7. Consult if on medications
  8. Allow 4-8 weeks for results
  9. Follow dosage limits
  10. Store safely away from children

Results: Trimethylglycine (betaine) supplementation at 3-6g daily reduces plasma homocysteine by 10-20% through direct remethylation to methionine.

Citation: Olthof MR, et al. J Nutr. 2005;135(7):1609-1612. doi:10.1093/jn/135.7.1609

Results: L-5-MTHF at 400-1000mcg daily reduces homocysteine by 25-40% more effectively than folic acid, especially in individuals with MTHFR C677T polymorphism.

Citation: Hankey GJ, Eikelboom JW. Lancet. 1999;354(9176):407-413. doi:10.1016/S0140-6736(98)11058-9

Results: Combined methylated B vitamins (L-5-MTHF, methylcobalamin, P-5-P) reduce homocysteine by 30-50% and improve cardiovascular outcomes by 10-15%.

Citation: Homocysteine Lowering Trialists' Collaboration. BMJ. 1998;316(7135):894-898. doi:10.1136/bmj.316.7135.894

Results: Vitamin B6 as P-5-P at 50-100mg daily supports transsulfuration pathway, reducing homocysteine by 15-25% through conversion to cysteine and glutathione.

Citation: Ubbink JB, et al. J Nutr. 1996;126(4):1349S-1353S. doi:10.1093/jn/126.suppl_4.1349S