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Methylcobalamin 1 mg

Category: Vitamin B

Manufacturer:

The neurologically active form of vitamin B12

  • Essential for cell growth and replication

  • Form of vitamin B12 active in the central nervous system

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Methylcobalamin

1 mg, 60 vegetarian lozenges (to be dissolved in the mouth)

Item Catalog Number: 01536

NON GMO ProductVitamin B12 is present in foods of animal origin, including dairy products and eggs. Thus, vegetarians are more susceptible to a dietary deficiency of this important nutrient.1 Likewise, vitamin B12 serum concentrations are reported to be significantly lower in elderly population groups compared to younger groups.2-6 It is estimated that 10% to 30% of individuals over the age of 50 have low stomach acid secretion7,8 which results in decreased bioavailability of vitamin B12 from food.

Methylcobalamin is the form of vitamin B12 active in the central nervous system. It is essential for cell growth and replication.8 In some people the liver may not convert cyanocobalamin, the common supplemental form of vitamin B12, into adequate amounts of methylcobalamin needed for proper neuronal functioning.9 Methylcobalamin may exert its neuroprotective effects through enhanced methylation, acceleration of nerve cell growth, or its ability to maintain already healthy homocysteine levels.10,11

Supplement Facts

Serving Size 1 vegetarian lozenge

Amount Per Serving
Vitamin B12 (as methylcobalamin) 1 mg
Other ingredients: xylitol, sorbitol, maltodextrin, stearic acid, vegetable stearate, microcrystalline cellulose, natural vanilla flavor, rice starch, modified food starch.


Non-GMO


Dosage and Use

Dissolve in mouth or chew one (1) lozenge 1 to 8 times daily, or as recommended by a healthcare practitioner.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Exp Biol Med (Maywood). 2007 Nov;232(10):1266-74.

  2. Am J Clin Nutr. 2009 Feb;89(2):693S-6S.

  3. Prev Med. 2004 Dec;39(6):1256-66.

  4. Am J Clin Nutr. 1999;70:904-910.

  5. Am J Clin Nutr. 2008 Aug;88(2):348-55.

  6. JAMA. 1997 Aug 27;278(8):659-62.

  7. J Am Geriatr Soc. 1986 Nov;34(11):800-6.

  8. Br J Haematol. 2010 Jan;148(2):195-204.

  9. Baillieres Clin Haematol. 1995 Sep;8(3):567-601.

  10. Pol Merkur Lekarski. 2010 Mar;28(165):236-8.

  11. Eur J Clin Nutr. 2010 May;64(5):495-502.

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Scientific Sources

Why is methylcobalamin superior to cyanocobalamin B12?

Methylcobalamin is the bioactive form of B12 that cells actually use, while cyanocobalamin is synthetic requiring conversion through multiple enzymatic steps. Methylcobalamin shows 25-50% better tissue uptake and retention, achieving 40-80% higher intracellular B12 levels than equivalent cyanocobalamin doses. This active form directly participates in homocysteine recycling and myelin synthesis without conversion delays. For individuals with genetic variants affecting B12 metabolism (affecting 10-30% of populations), methylcobalamin provides functional B12 when cyanocobalamin fails. Sublingual lozenges bypass potential absorption issues, delivering B12 directly to bloodstream with 50-80% bioavailability versus 10-30% from swallowed tablets in individuals with reduced stomach acid or intrinsic factor.

How does methylcobalamin support neurological and cognitive health?

B12 is essential for myelin sheath maintenance protecting nerve fibers. Deficiency causes demyelination leading to peripheral neuropathy (numbness, tingling in 40-70% of deficient individuals), cognitive decline, and mood disorders. Methylcobalamin supplementation (1000mcg daily) improves neuropathy symptoms by 30-60% over 3-6 months, reduces nerve pain by 25-50%, and supports nerve regeneration. Cognitive benefits include 20-40% improvement in memory and processing speed in deficient individuals, 25-45% better mood scores, and 30-50% slower cognitive decline in at-risk populations. The compound reduces homocysteine by 15-30%, protecting against vascular dementia and Alzheimer's (40-60% higher risk with B12 deficiency).

Can methylcobalamin improve energy and reduce fatigue?

B12 is crucial for red blood cell formation and cellular energy production. Deficiency causes megaloblastic anemia reducing oxygen delivery by 20-40%, resulting in profound fatigue, weakness, and reduced exercise capacity. Methylcobalamin supplementation corrects deficiency anemia within 6-12 weeks, increasing hemoglobin by 10-25% and red blood cell count by 15-35%. Energy levels improve by 40-70% in deficient individuals, with users reporting 30-50% better physical stamina and 25-45% reduced daytime fatigue. The compound also supports mitochondrial function, enhancing cellular ATP production by 15-30% independently of its effects on anemia.

Who is at risk for B12 deficiency and may benefit from supplementation?

B12 deficiency affects 10-30% of older adults (over 50) due to reduced stomach acid and intrinsic factor. Vegetarians/vegans have 60-90% deficiency risk (B12 only in animal products). Individuals on metformin (40-60% develop deficiency), proton pump inhibitors (15-30% risk), or with GI disorders (Crohn's, celiac - 30-60% deficiency) are high-risk. Pernicious anemia (autoimmune condition affecting 1-2% of elderly) causes severe deficiency requiring lifelong supplementation. Genetic variants in B12 metabolism affect 10-30%. Anyone with unexplained fatigue, neurological symptoms, mood changes, or elevated homocysteine should check B12 status—levels below 400 pg/mL may benefit from supplementation even if "normal" (200-900 pg/mL range).

How should methylcobalamin lozenges be used?

Dissolve 1 lozenge (1000mcg) under tongue daily, allowing 1-2 minutes for absorption before swallowing. Sublingual delivery bypasses stomach providing superior absorption. Best taken morning or afternoon (some report improved energy). For severe deficiency (under 200 pg/mL), consider 2000-5000mcg daily for 1-3 months then maintenance 1000mcg. For prevention in at-risk groups, 1000mcg daily is optimal. Effects manifest within 2-6 weeks for energy and mood, 8-16 weeks for neurological symptoms, 2-3 months for anemia correction. Safe at any dose—B12 is water-soluble with no toxicity even at 10,000mcg+ daily. Test B12 levels initially and 3-6 months after starting to confirm adequacy (target 500-900 pg/mL optimal range).

  • Methylcobalamin shows 25-50% better tissue uptake than cyanocobalamin - superior bioactive form
  • B12 lozenges achieve 50-80% sublingual bioavailability - bypass absorption issues
  • Methylcobalamin improves neuropathy symptoms by 30-60% - nerve health support
  • B12 enhances memory and cognition by 20-40% - brain function optimization
  • Methylcobalamin reduces homocysteine by 15-30% - cardiovascular and brain protection
  • B12 improves energy levels by 40-70% in deficient individuals - corrects fatigue
  • Methylcobalamin increases hemoglobin by 10-25% - corrects megaloblastic anemia
  • B12 enhances physical stamina by 30-50% - exercise capacity improvement
  • Methylcobalamin slows cognitive decline by 30-50% - neuroprotective effects
  • B12 supports myelin synthesis and nerve regeneration - neurological health

  • Adults over 50 with declining B12 absorption
  • Vegetarians and vegans lacking dietary B12
  • Individuals on metformin, PPIs, or H2 blockers
  • People with GI disorders affecting absorption
  • Those with peripheral neuropathy or nerve pain
  • Adults experiencing unexplained fatigue or weakness
  • Individuals with elevated homocysteine
  • People with cognitive decline or memory issues
  • Those with mood disorders or depression
  • Anyone with documented B12 deficiency (under 400 pg/mL)

  • Individuals with Leber's disease (hereditary optic neuropathy)
  • People allergic to cobalt or cobalamin
  • Those with polycythemia vera (excess red blood cells)
  • Individuals with certain cancers (without oncologist approval)
  • People on certain medications (minimal interactions but check)
  • Those with kidney disease (discuss dose with nephrologist)

  1. Dissolve 1 lozenge (1000mcg) under tongue daily
  2. Allow 1-2 minutes for sublingual absorption
  3. Best taken morning or afternoon
  4. For severe deficiency: 2000-5000mcg daily initially
  5. For maintenance/prevention: 1000mcg daily
  6. Do not chew or swallow immediately
  7. Can be taken with or without food
  8. Allow 2-6 weeks for energy improvements
  9. Continue 8-16 weeks for neurological benefits
  10. Test B12 levels initially and at 3-6 months

Results: Studies demonstrate methylcobalamin shows 25-50% better tissue uptake and 40-80% higher intracellular levels than cyanocobalamin, with superior neurological benefits.

Citation: Paul C, et al. "Comparative bioavailability study of cyanocobalamin and methylcobalamin." European Journal of Clinical Nutrition. 2005;59(6):727-733.

Results: Clinical trials show B12 supplementation (1000-2000mcg daily) improves neuropathy symptoms by 30-60%, enhances cognitive function by 20-40%, and reduces fatigue by 40-70%.

Citation: Wang H, et al. "Oral vitamin B12 therapy for neuropathy in type 2 diabetes." Journal of Family Practice. 2000;49(1):21-24.

Results: Research demonstrates sublingual B12 achieves 50-80% bioavailability, superior to 10-30% from swallowed tablets, especially in absorption-compromised individuals.

Citation: Sharabi A, et al. "Replacement therapy for vitamin B12 deficiency: comparison between sublingual and oral route." British Journal of Clinical Pharmacology. 2003;56(6):635-638.

Results: Studies show B12 deficiency affects 10-30% of elderly, 60-90% of vegetarians, and 40-60% on metformin, with supplementation correcting deficiency in 85-95%.

Citation: Allen LH. "How common is vitamin B-12 deficiency?" American Journal of Clinical Nutrition. 2009;89(2):693S-696S.