Optimized Tryptophan Plus

Category: Nervous system and neurotransmitters


Lessen stress, enhance rest, & eat less

  • Your body requires tryptophan to produce and maintain optimum serotonin levels

  • Has been shown to improve sleep, enhance mood, and modulate stress

  • Provides a unique, balanced supply of other nutrients to provide nutritive support for the body’s production of serotonin

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Optimized Tryptophan Plus

90 vegetarian capsules

Item Catalog Number: 01721

NON GMO ProductSerotonin is a neurotransmitter in the brain associated with positive moods and restful sleep.1-4 To produce and maintain optimum serotonin levels, your body requires tryptophan, an essential amino acid the body can’t produce.1

In the body, tryptophan has been shown to improve sleep,3,4 enhance mood,1,2,4 and modulate stress.5 So Life Extension offers Optimized Tryptophan Plus to broadly and powerfully support tryptophan levels already within the normal range.

The basis for this formula is premium L-tryptophan, which has undergone significantly more rigorous manufacturing processes than regular tryptophan material to assure the highest purity and safety.

In addition to an optimum amount of premium tryptophan … this formula also provides a unique, balanced supply of other nutrients found to help maintain tryptophan activity in the body.6-8 Those nutrients include lysine, niacinamide, and extracts of hops and rosemary to provide nutritive support for the body’s production of serotonin.

Supplement Facts

Serving Size 3 vegetarian capsules

Servings Per Container 30

Amount Per Serving
Niacin (as niacinamide) 66 mg
L-Tryptophan 1000 mg
L-Lysine (as L-Lysine HCl) 250 mg
Proprietary Tryptophan Plus Blend 285 mg
Perluxan® Hops standardized extract (cones), Ursole™ Rosemary standardized extract (leaf)
Other ingredients: vegetable cellulose (capsule), maltodextrin, modified food starch, hydroxypropyl methylcellulose, microcrystalline cellulose, stearic acid, silica.


Perluxan® is used by permission.

Ursole™ is a trademark of Vitiva d. d., Slovenia.

Dosage and Use

Take up to three (3) capsules all at once before bedtime, or one capsule on an empty stomach before each meal, or as recommended by a healthcare practitioner.

For maximum absorption take with a small amount of carbohydrate, such as diluted juice.

Best if taken separately from protein or amino acids.


Serotonin syndrome is characterized by high levels of serotonin and symptoms like confusion, sweating, agitation, nausea, involuntary muscle contractions, and racing heartbeat. Do not take L-tryptophan if you experience these symptoms. Because tryptophan may have numerous drug interactions (most commonly, MAOIs and SSRIs) consult your healthcare provider before taking this product if you are taking prescription medications. Do not use before driving or operating heavy machinery.




Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Int J Neurosci. 1992 Nov-Dec;67(1-4):127-44.

  2. Curr Opin Neurobiol. 2013 Feb 2. pii: S0959-4388(13)00027-5.

  3. Prog Neurobiol. 2000 Jan;60(1):13-35.

  4. J Nutr. 2012 Dec;142(12):2236S-2244S.

  5. J Exp Biol. 2002 Dec;205(Pt 23):3679-87.

  6. Available at: http://www.tamu.edu/faculty/bmiles/lectures/ amcat.pdf. Accessed February 14, 2013.

  7. Amino Acids. 2012 June 8.

  8. J Clin Invest. 1999 April 15;103(8):1169–78.

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