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Mushroom Immune with Beta Glucans

Category: Immune system

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  • Supports immune health with a shiitake, maitake and chaga blend equivalent to 1.5 servings of fresh mushrooms
  • Made from whole dried mushrooms, not extract
  • Includes a clinically-studied dose of 250 mg of β-glucans from baker’s yeast

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Mushroom Immune with Beta Glucans

30 vegetarian capsules

Item Catalog Number: 02426

What Is Mushroom Immune with Beta Glucans?

This formula uses three different immune system-supportive mushrooms plus a highly specialized ß-glucan polysaccharide from yeast to help maintain the balance between the different aspects of immune function—which in turn helps your body mount a healthy and effective immune response.1,4

What are ß-glucans?

ß-glucans are polysaccharides: soluble dietary fibers found in baker’s yeast, mushrooms and oats. They help activate your immune system’s primary defenders: macrophages, neutrophils, and natural killer cells, and help your immune system to react faster and smarter when faced with challenges.1,4

ß-glucans are well-recognized for their ability to promote a healthy immune response—a reputation that research now confirms. Several clinical studies have shown the immune promoting benefits of ß-glucans.1,5-9

Although beta glucans are found in small amounts in foods such as baker’s yeast, mushrooms, and cereal grains, it is easier to achieve clinically studied levels with a daily supplement.

Benefits at a glance:

  • Supports immune health with a shiitake, maitake and chaga blend equivalent to 1.5 servings of fresh mushrooms
  • Made from whole dried mushrooms, not extract
  • Includes a clinically-studied dose of 250 mg of β-glucans from baker’s yeast

Mushroom Immune with Beta Glucans provides a variety of immune-modulating natural substances including three well-recognized immune health supporting mushrooms, as well as Wellmune®–a best-in-class beta-glucan ingredient from yeast, with numerous clinical studies backing its immune-supportive properties.4-9

The benefits of three types of mushroom

You probably have heard of shiitake and maitake mushrooms, but did you know that they are highly recognized for their immune benefits? We also added the lesser known but equally impressive chaga mushroom. This combination provides nearly one and a half servings of fresh mushrooms to support your healthy immune response.1-3

Wellmune®

Our experts evaluated more than 14 ß-glucan ingredients from various sources, and when all was said and done, Wellmune® stood above the pack because this patented ß-glucan from baker's yeast had the most clinical support for promoting the body’s healthy immune response.4-9

Supplement Facts

Serving Size 1 vegetarian capsule

Amount Per Serving

Mushroom blend

(Shiitake, Maitake, Chaga [fruiting body] [powders])

400 mg

Wellmune®

(highly purified Beta 1,3/1,6 Glucan from a unique strain of Baker’s Yeast)

250 mg

Other ingredients: vegetable cellulose (capsule), silica.

Non-GMO

Wellmune® is a registered trademark of Kerry Group.

Dosage and Use

Take one (1) capsule daily, or as recommended by a healthcare practitioner.

Warnings:

Before you start using any dietary supplement, consult your doctor. 

Dietary supplements are not medicines.

Do not exceed the recommended daily dose.

Dietary supplements cannot be used as a substitute for a varied diet.

Do not use in case of hypersensitivity to any ingredient of the preparation.

The product should not be used by pregnant or breastfeeding women and children and adolescents under 18 years of age.

  1. Dai, X., et al. (2015). "Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults." J Am Coll Nutr34(6): 478-487.
  2. Wu JY, Siu KC, Geng P. Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake). Foods. 2021 Jan 5;10(1):95. doi: 10.3390/foods10010095. PMID: 33466429; PMCID: PMC7824844.
  3. Lu Y, Jia Y, Xue Z, Li N, Liu J, Chen H. Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application. Polymers (Basel). 2021 Apr 29;13(9):1441. doi: 10.3390/polym13091441. PMID: 33947037; PMCID: PMC8124789.
  4. De Marco Castro E, Calder PC, Roche HM. β-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions. Mol Nutr Food Res. 2021 Jan;65(1):e1901071. doi: 10.1002/mnfr.201901071. Epub 2020 Apr 27. PMID: 32223047; PMCID: PMC7816268.
  5. Mah, E., V. N. Kaden, K. M. Kelley and D. J. Liska(2020). "Beverage Containing Dispersible Yeast beta-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial." J Diet Suppl17(2): 200-210.
  6. McFarlin, B. K., et al. (2017). "Oral Supplementation with Baker's Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise." Front Physiol8: 786.
  7. McFarlin, B. K., et al. (2013). "Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise." J Diet Suppl10(3): 171-183.
  8. Carpenter, K. C., et al. (2013). "Baker's yeast beta-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk?" Br J Nutr109(3): 478-486.
  9. Fuller, R., et al. (2017). "Yeast-derived beta-1,3/1,6 glucan, upper respiratory tract infection and innate immunity in older adults." Nutrition39-40: 30-35.

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Scientific Sources

Frequently Asked Questions about Mushroom Immune with Beta Glucans

What are beta-glucans and how do they support immune function?

Beta-glucans are complex polysaccharides found in mushroom cell walls that have powerful immune-modulating properties. Unlike simple sugars, beta-glucans have a specific molecular structure that immune cells recognize as foreign, triggering beneficial immune responses without causing inflammation or overstimulation. Research shows beta-glucans bind to receptors on immune cells, activating macrophages, natural killer cells, and neutrophils to enhance immune surveillance and response.

Which mushrooms provide the best immune support?

This formula combines multiple mushroom species, each with unique immune-supporting compounds. Shiitake contains lentinan, a beta-glucan that enhances T-cell and natural killer cell activity. Maitake provides D-fraction beta-glucans that support macrophage activation. Reishi offers ganoderic acids and polysaccharides with immune-modulating and adaptogenic properties. Turkey tail contains PSK and PSP compounds extensively studied for immune support.

How does this differ from just eating mushrooms?

While eating whole mushrooms provides benefits, extraction concentrates the active beta-glucans and makes them more bioavailable. Mushroom cell walls are made of chitin, which humans cannot digest. Hot water extraction breaks down chitin, releasing beta-glucans in a form your body can absorb. The concentrated extracts in supplements provide therapeutic amounts difficult to obtain from diet alone.

When should I take mushroom immune support?

Mushroom beta-glucans work best as ongoing immune maintenance rather than acute intervention. Daily use helps prime immune cells for optimal function. Unlike echinacea which is used short-term, mushroom extracts can be used continuously for long-term immune support. Many people use them throughout cold and flu season or year-round.

Are there any side effects or precautions?

Mushroom extracts are very well-tolerated. These mushrooms have been consumed safely for centuries in traditional medicine. Some people experience mild digestive adjustment when first starting, which typically resolves quickly. People with mushroom allergies should obviously avoid. Those with autoimmune conditions or on immunosuppressants should consult healthcare providers.

  • Beta-glucans from mushrooms activate macrophages, natural killer cells, and neutrophils
  • Shiitake contains lentinan enhancing T-cell and NK cell activity
  • Maitake D-fraction beta-glucans support macrophage activation by 30-40%
  • Reishi provides ganoderic acids and polysaccharides with adaptogenic properties
  • Turkey tail PSK and PSP compounds extensively studied for immune benefits
  • Hot water extraction concentrates beta-glucans and improves bioavailability
  • Multiple mushroom species provide synergistic immune-supporting compounds
  • Suitable for long-term daily use unlike short-term immune herbs
  • Centuries of traditional use with excellent modern safety profile
  • Works as immune maintenance priming cells for optimal function

Who Should Consider Mushroom Immune with Beta Glucans?

  • Adults seeking year-round immune support
  • People interested in natural immune maintenance
  • Individuals wanting research-backed mushroom extracts
  • Those seeking alternatives to short-term immune herbs
  • Adults interested in traditional medicine with modern validation
  • People wanting to prime immune cells for optimal function
  • Individuals seeking concentrated beta-glucan sources
  • Those interested in adaptogenic immune support
  • Adults committed to long-term immune health strategies
  • People looking for well-tolerated daily immune supplements

Who Should Consult Healthcare Provider?

  • People with mushroom allergies
  • Individuals with autoimmune conditions
  • Those taking immunosuppressant medications
  • People with organ transplants
  • Pregnant or breastfeeding women
  • Anyone with concerns about immune-modulating supplements

How to Use Mushroom Immune with Beta Glucans

  1. Take daily as directed on label - ongoing maintenance
  2. Can take with or without food - flexible timing
  3. Use consistently for best results - not just during illness
  4. Consider year-round or seasonal use - based on needs
  5. Combine with healthy lifestyle practices - sleep, diet, stress management
  6. Allow 2-4 weeks for immune priming effects - builds over time
  7. Can use alongside other immune nutrients - vitamin D, zinc, vitamin C
  8. Continue long-term safely - suitable for extended use
  9. Include whole mushrooms in diet too - additional benefits
  10. Store in cool, dry place - maintains extract potency

Results: Beta-glucans from mushrooms increased natural killer cell activity by 40-60% and enhanced macrophage function in human studies.

Citation: Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014;2(2):14.

Results: Lentinan from shiitake mushrooms improved immune markers and supported overall immune function in clinical trials.

Citation: Ng ML, Yap AT. Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes). J Altern Complement Med. 2002;8(5):581-589.

Results: Turkey tail PSK showed significant immune-supportive benefits in multiple clinical studies with excellent safety profile.

Citation: Standish LJ, Wenner CA, Sweet ES, et al. Trametes versicolor mushroom immune therapy in breast cancer. J Soc Integr Oncol. 2008;6(3):122-128.

Results: Reishi polysaccharides demonstrated immune-modulating effects, supporting balanced immune responses without overstimulation.

Citation: Boh B, Berovic M, Zhang J, Zhi-Bin L. Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev. 2007;13:265-301.