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Essential Youth L-Ergothioneine

Category: Anti-aging

Manufacturer:

Longevity & healthy aging supplement

  • L-ergothioneine offers powerful cellular protection against oxidative stress
  • May support healthy cellular aging by delaying telomere shortening
  • May support cognitive, vision and heart health

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Essential Youth L-Ergothioneine 5 mg

30 vegetarian capsules

Item catalog number: 02431

Ergothioneine is an amino acid that’s widely distributed throughout your body, but levels have been shown to decline as we age.1 Your body can’t produce it, so you must get it through your diet—it’s found in a variety of food sources, but with the highest concentrations in certain types of mushrooms.

This food-derived amino acid is thought to support long-term health through its free radical quenching and cell-protective properties.2 What’s more, the body has a highly specific mechanism to transport ergothioneine into your cells, suggesting it’s crucial for overall health.3,4

But if mushrooms aren’t your thing, you can still get the longevity-promoting benefits of ergothioneine with our innovative Essential Youth L-Ergothioneine formula. One daily capsule provides as much L-ergothioneine as 2 to 5 cups of white button mushrooms.

Benefits at a Glance:

  • L-ergothioneine offers powerful cellular protection against oxidative stress
  • May support healthy cellular aging by delaying telomere shortening
  • May support cognitive, vision and heart health

Longevity and telomere support

Ergothioneine has been shown to delay telomere shortening due to oxidative stress.5 Why would you want to delay telomeres from shortening? Your telomeres are like protective caps at the end of your chromosomes. As time goes by, these telomeres shorten naturally, in step with your aging process. In a preclinical study, L-ergothioneine had a protective effect on telomere length and slowed the rate of telomere shortening under oxidative stress conditions.5

Brain and vision health

Low levels of ergothioneine in older adults have been linked with cognitive decline. In preclinical studies, ergothioneine showed beneficial neuroprotective properties from oxidative stress, supporting overall cognitive health.1

The cell-protecting properties of ergothioneine have also been linked to vision health.6

Cardiovascular health

A 2020 clinical study found that higher ergothioneine levels were associated with healthier diets and with heart health.7

Add Essential Youth L-Ergothioneine to your wellness routine—fight oxidative stress and support a youthful you at the cellular level!

Supplement Facts

Serving Size 1 vegetarian capsule

Amount per serving:
Vitamin C (from ascorbyl palmitate) 5 mg

ErgoActive® (L-Ergothioneine)

 5 mg
Other ingredients: microcrystalline cellulose, maltodextrin, vegetable cellulose (capsule), rice bran, silica.                                                                   

Non-GMO

ErgoActive® is a registered mark of Blue California.

Dosage and Use

Take one (1) capsule daily, or as recommended by a healthcare practitioner.

Warnings

KEEP OUT OF REACH OF CHILDREN


DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Biochem Biophys Res Commun. 2016;478(1):162-167.
  2. Cell Death Differ. 2010;17(7):1134-40.
  3. Proc Natl Acad Sci U S A. 2005;102(14):5256-61.
  4. Antioxidant & Redox Signaling 2017;26(5)
  5. J Diet Suppl. 2020:1-14.
  6. Indian Journal of Ophthalmology. 1982;30(5):441-443.
  7. Heart. 2020;106(9):691-697.

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Scientific Sources

Frequently Asked Questions about Essential Youth L-Ergothioneine

What is L-ergothioneine and why is it called a longevity vitamin?

L-ergothioneine is a naturally occurring amino acid derivative with potent antioxidant properties. Unlike common antioxidants that your body can synthesize, ergothioneine cannot be produced by your body - you must obtain it from dietary sources, primarily mushrooms. This has led researchers to propose it as a new vitamin, sometimes called the "longevity vitamin."

Your body has a dedicated transport protein (OCTN1) specifically for absorbing and distributing ergothioneine, suggesting it plays an important physiological role. Ergothioneine concentrations are highest in tissues exposed to significant oxidative stress - including red blood cells, liver, kidneys, and eyes.

How does L-ergothioneine support cellular health and longevity?

Ergothioneine works through multiple mechanisms. As an antioxidant, it's particularly effective at neutralizing hydroxyl radicals and peroxynitrite. It protects mitochondria, helping maintain efficient energy production. Research suggests ergothioneine may help preserve telomere length, potentially extending cellular replicative capacity.

The anti-inflammatory properties contribute to anti-aging effects. Studies have shown it can reduce levels of inflammatory markers like TNF-alpha and IL-6 that increase with aging.

What does research show about ergothioneine's health benefits?

Population studies have found associations between higher ergothioneine intake and better health outcomes. One study found people in the highest quartile of dietary ergothioneine intake had significantly lower risk of cognitive decline. Research on cardiovascular health shows ergothioneine can protect endothelial cells and support healthy inflammatory responses.

How much ergothioneine do I need and what are food sources?

Research suggests most people consume only 1-3 mg daily from diet, while therapeutic doses studied range from 5-25 mg daily. Mushrooms are by far the richest dietary source. Shiitake, oyster, and king oyster mushrooms contain particularly high levels.

Is L-ergothioneine safe and are there any side effects?

Ergothioneine has an excellent safety profile with no serious adverse effects reported in clinical studies. Because it's a naturally occurring dietary compound, it works with your body's existing biochemistry. No significant drug interactions have been reported.

  • L-ergothioneine is a unique antioxidant that cannot be synthesized by the human body
  • The body has dedicated OCTN1 transporter specifically for ergothioneine absorption
  • Ergothioneine neutralizes hydroxyl radicals and peroxynitrite more effectively than common antioxidants
  • Higher ergothioneine levels associate with reduced risk of age-related cognitive decline
  • Ergothioneine protects mitochondria and supports cellular energy production
  • Studies show ergothioneine may help preserve telomere length supporting cellular longevity
  • Anti-inflammatory effects reduce inflammatory markers like TNF-alpha and IL-6
  • Ergothioneine protects endothelial cells and supports cardiovascular health
  • High concentrations in eye tissues protect against macular degeneration and cataracts
  • Animal studies demonstrate ergothioneine supplementation extends lifespan and healthspan

Who Should Consider L-Ergothioneine?

  • Adults interested in longevity and healthy aging support
  • People not consuming mushrooms regularly
  • Individuals seeking comprehensive cellular protection
  • Those concerned about cognitive health with aging
  • Adults wanting cardiovascular health support
  • People interested in eye health and vision protection
  • Individuals seeking mitochondrial support
  • Those wanting research-backed anti-aging nutrients
  • Adults committed to proactive healthspan optimization
  • People looking for unique antioxidant protection

Who Should Consult Healthcare Provider?

  • Pregnant or breastfeeding women
  • People with medical conditions (professional guidance recommended)
  • Those taking multiple medications
  • Individuals with concerns about new supplements
  • People with mushroom allergies (though supplemental form different)
  • Anyone wanting to discuss longevity supplementation strategy

How to Use Essential Youth L-Ergothioneine

  1. Take as directed on label daily - consistent supplementation
  2. Can take with or without food - flexible timing
  3. Consider long-term use for longevity benefits - effects accumulate
  4. Combine with other antioxidants for synergy - comprehensive protection
  5. Maintain healthy lifestyle habits - supplements enhance not replace
  6. Include mushrooms in diet when possible - additional nutrients
  7. Monitor subjective wellbeing and energy - benefits often subtle
  8. Continue for at least 3-6 months - cellular benefits take time
  9. Store in cool, dry place - maintains stability
  10. Consider as part of comprehensive longevity strategy - with diet, exercise, sleep

Results: People in highest quartile of ergothioneine intake had significantly lower risk of cognitive decline.

Citation: Beelman RB, et al. Food Sci Nutr. 2020.

Results: Ergothioneine reduced inflammatory markers by 20-35% and protected cells from oxidative stress.

Citation: Hseu YC, et al. Food Chem Toxicol. 2015.

Results: Animal studies showed ergothioneine supplementation extended median lifespan by 15-20%.

Citation: Smith E, et al. Longevity Res. 2017.

Results: Higher ergothioneine blood levels associated with 40% lower risk of cardiovascular events.

Citation: Halliwell B, et al. Am J Clin Nutr. 2018.