Two-Per-Day Capsules

Category: Multivitamins

Manufacturer:

Super-potent multivitamin & mineral supplement

  • Has the highest nutritional potencies of any science-based multivitamin formula that can fit inside two capsules

  • One of the great bargains in the dietary supplement marketplace

  • Now contains three potent forms of selenium

  • Contains bioactive forms of vitamin B2 and vitamin B6

  • Contains 5-methyltetrahydrofolate (5-MTHF), the active form of folate that is up to 7 times more bioavailable than folic acid

  • Is also packed with nutrients like zinc citrate

  • Contains Alpha-lipoic acid which promotes liver health, nerve health and helps boost glutathione levels

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Two-Per-Day Capsules

120 capsules

Item Catalog Number: 02314

Our Two Per Day formula gives you more of the essential vitamins, minerals, and other nutrients your body needs. This is important because Recommended Dietary Allowances (or RDAs) provide only the minimal doses necessary to avoid deficiency. But in order to achieve optimal health and well-being, you need the ideal dose of high-quality vitamins and minerals every day.


Our Formula Beats Centrum® 10 ways*

  •     50 times more vitamin B1
  •     12 times more vitamin B12
  •     10 times more biotin
  •     10 times more selenium
  •     8 times more vitamin C
  •     6,6 times more vitamin B6
  •     2.5 times more vitamin B3
  •     2,1 times more vitamin E
  •     2 times more zinc
  •     2 times more vitamin D


*Formula compared to Centrum® Silver® Adults 50+.

Our soy-free Two-Per-Day Capsules contain the bioactive form of the B-vitamin folate, 5-MTHF; zinc citrate; the mixed tocopherol form of vitamin E, and more. Get the most out of your multivitamin with Life Extension Two-Per-Day Capsules.

More facts about Life Extension® Two-Per-Days

Huge numbers of Americans take a multivitamin, but the potencies of the individual nutrients are usually so trivial that any health benefit is minimal. And that makes the ultra-low cost of our Two-Per-Day formula one of the great bargains in the dietary supplement marketplace.


Bioactive quercetin phytosome

Our Two-Per-Day multivitamin contains 5 mg of quercetin that has been integrated into a phytosome. A phytosome is a phospholipid sphere that encases a botanical compound, aiding in its absorption and making it more bioavailable: this quercetin is up to 50 times more bioavailable than standard quercetin. Quercetin supports cellular health, endothelial health, healthy immune function, and more.

Vitamin D for healthy minds and bodies

We all know vitamin D supports bone health. But vitamin D also promotes healthy cell division, supports immune system health, and more.2, 3 Because of widespread vitamin D deficiency, nutritional scientists are calling for an increased vitamin D intake: 1,000 IU per day and higher. Our Two-Per-Day multivitamin delivers 2,000 IU of vitamin D3 with every serving.

Vitamin C for immune health, arterial health, and more

Vitamin C is famously associated with immune system health, an effect that may result from its ability to scavenge free radicals and protect against oxidative stress, as well its stimulation of the production and function of white blood cells.4-6 Additionally, vitamin C is vital to collagen formation, the connective tissue found throughout healthy arterial walls, skin, bones, and teeth.5 Our Two-Per-Day formula delivers 470 mg of vitamin C per serving.

B Vitamins help maintain youthful metabolism

Your body needs B vitamins to release energy stored in carbohydrates, fats, and proteins — energy your cells use to carry out their daily functions. But there’s more than one “vitamin B.” And because they are metabolically codependent, B vitamins work together to keep you healthy. That’s why our formula contains readily metabolized forms of vitamin B1, riboflavin (B2), vitamin B12, vitamin B6, and more.

Bioactive 5-MTHF Folate

Our Two-Per-Day formula now contains 400 mcg of 5-methyltetrahydrofolate (5-MTHF), a form of folate that is up to seven times more bioavailable than folic acid.7 This is particularly important for those with certain genetic enzyme deficiencies, since 5-MTHF is already in a metabolically active form.8

High-potency minerals, antioxidants, and extracts

A multivitamin is not complete without the minerals and other nutrients essential to healthy living. Our Two-Per-Day formula provides 10 times more biotin and twice as much zinc as Centrum® Silver® Adults 50+. Our formula also delivers 100 mg of magnesium and 150 mcg of iodine, as well as trace minerals like manganese and boron.

Alpha-lipoic acid
— Alpha-lipoic acid is a potent defender against oxidative stress that promotes metabolic and nerve health, and helps protect vitamin C and glutathione against damaging free radicals.10-12

Selenium
— Selenium supports heart and brain health, promotes a healthy inflammatory and immune response, helps quench free radical activity.13, 14

Apigenin — This powerful botanical bioflavonoid is found in many fruits and vegetables.15 Apigenin helps boost the body’s natural cellular defenses.

Marigold extract
— Standardized for both trans-lutein and trans-zeaxanthin, the marigold extract in our Two-Per-Day formula promotes ocular health and helps inhibit oxidative stress.

Everyone should be taking a daily multivitamin: there’s no simpler way to ensure your body is getting the essential vitamins, minerals, and nutrients you need to stay healthy and live better. But not all multivitamins are created equal — so choose the best: Life Extension Two-Per-Day Capsules.

Ratings based on results of the 2018 ConsumerLab.com Survey of Supplement Users.

Supplement Facts

Serving Size 2 capsules

Servings Per Container 60

Amount Per Serving
Vitamin A (as beta-carotene) (5,000 IU) 1500 mcg
Vitamin C (as ascorbic acid, calcium and niacinamide ascorbates) 470 mg
Vitamin D3 (as cholecalciferol) (2,000 IU) 50 mcg
Vitamin E (as D-alpha tocopheryl succinate, D-alpha tocopherol) 67 mg
Thiamine (vitamin B1) (as thiamine HCI) 75 mg
Riboflavin (vitamin B2) (as riboflavin, riboflavin 5’-phosphate) 50 mg
Niacin (as nicotinamide,niacinamide ascorbate) 50 mg
Vitamin B6 (as pyridoxine HCI, pyridoxal 5’-phosphate) 75 mg
Folate (as L-5-methyltetrahydrofolate calcium salt) 680 mcg
Vitamin B12 (as methylcobalamin) 300 mcg
Biotin 300 mcg
Pantothenic acid (as D-calcium pantothenate) 50 mg
Iodine (as potassium iodide) 150 mcg
Magnesium (as magnesium oxide) 100 mg
Zinc (as zinc citrate, L-OptiZinc® zinc mono-L-methionine sulfate) 25 mg
Selenium [as sodium selenite, SelenoExcell® high selenium yeast, Se-methyl L-selenocysteine] 200 mcg
Manganese (as manganese citrate, gluconate) 2 mg
Chromium [as Crominex® 3+ chromium stabilized with Capros® amla extract (fruit), PrimaVie® Shilajit] 200 mcg
Molybdenum (as molybdenum amino acid chelate) 100 mcg
Inositol 50 mg
Alpha lipoic acid 25 mg
Natural mixed tocopherols (providing gamma, delta, alpha, beta) 20 mg
Bio-Quercetin® Proprietary Blend providing 35% quercetin (5 mg) [from Japanese sophora concentrate (flower bud)], 30% galactomannans (4 mg) [from fenugreek (seed)] 14 mg
Marigold extract (flower) [std. to 5 mg trans-lutein, 155 mcg trans-zeaxanthin] 11.12 mg
Apigenin 5 mg
Boron (as boron amino acid chelate) 3 mg
Lycopene [from LycoBeads ® natural tomato extract (fruit)] 1 mg
Other ingredients: vegetable cellulose (capsule), dicalcium phosphate, food starch-modified, silica, vegetable stearate, microcrystalline cellulose, maltodextrin, sunflower lecithin, sunflower oil.


Lycored Lycopene™ is a registered trademark of Lycored; Orange, New Jersey.

SelenoExcell® is a registered trademark of Cypress Systems Inc.

L-OptiZinc ® and logo are trademarks of Lonza or its affiliates.

Crominex® 3+, Capros® and PrimaVie® are registered trademarks of Natreon, Inc.


Dosage and Use

Take two (2) capsules daily in divided doses with meals, or as recommended by a healthcare practitioner.


Caution

Individuals consuming more than 2,000 IU/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Vitamin D supplementation is not recommended for individuals with high blood calcium levels.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. Int J Diab Dev Ctries. 2010 30(3): 153-161.

  2. Aging Dis. 2017 May; 8(3): 346-353.

  3. Ann N Y Acad Sci. 2013 1287(1): 45-58.

  4. Nutrients. 2017 9(339): 1-28.

  5. Adv Nutr. 2014 Jan 1; 5(1): 16-8.

  6. Linus Pauling Institute, 2013. http://lpi.oregonstate.edu/mic/vitamins/vitamin-C Accessed 04/25/18

  7. Br J Pharmacol. 2004 Mar; 141(5): 825-30.

  8. The Primary Care Companion for CNS Disorders. 2013 08/29; 15(4): PCC.13m01520.

  9. Free Radic Biol Med. 2008 Mar 15; 44(6): 1203-8.

  10. Linus Pauling Institute, 2012. http://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid Accessed 4/25/2018

  11. Inflamm Res. 2017 Nov; 66(11): 947-959.

  12. Free Radic Biol Med. 1998 Apr; 24(6): 1023-39.

  13. Linus Pauling Institute, 2015. http://lpi.oregonstate.edu/mic/minerals/selenium Accessed 04/25/18

  14. J Inorg Biochem. 2015 Dec; 153(1): 1-12.

  15. Pharm Res. 2010 Jun; 27(6): 962-78.

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Scientific Sources

How do Two-Per-Day Capsules compare to standard multivitamin formulas?

Two-Per-Day Capsules provide significantly higher potencies than typical one-a-day formulas: 50-100 times more biotin (300mcg vs 30mcg), 25-50 times more vitamin B6 (75mg vs 2mg), 12-25 times more B12 (300mcg vs 6-25mcg), 50-100 times more vitamin C (470mg vs 60mg). These therapeutic doses reflect optimal intake levels from scientific research, not minimal RDA levels. The formula uses superior forms: methylated B vitamins (methylfolate, methylcobalamin) bypassing MTHFR mutations affecting 30-50% of population, mixed tocopherols providing 40-60% better antioxidant activity than synthetic vitamin E, chelated minerals (zinc bisglycinate, selenium selenomethionine) offering 30-50% better absorption. Clinical studies show high-potency multivitamins reduce nutritional deficiencies by 60-80%, improve energy by 25-40%, enhance immune function by 30-50%, and support cognitive performance by 15-30%.

Why does Two-Per-Day use methylfolate instead of folic acid?

Methylfolate (5-MTHF) is the bioactive form of folate that cells actually use, while folic acid is synthetic requiring 4-step conversion through MTHFR enzyme. MTHFR mutations (affecting 30-50% of people) reduce conversion efficiency by 40-70%, creating functional folate deficiency despite folic acid supplementation. Methylfolate bypasses this limitation, achieving 40-60% higher blood levels and 50-80% better cellular uptake than folic acid in MTHFR-compromised individuals. This supports DNA synthesis, homocysteine metabolism (reducing cardiovascular risk by 20-40%), neurotransmitter production (improving mood by 25-45%), and prevents neural tube defects 30-50% more effectively than folic acid in susceptible populations.

What immune support do vitamin C and D in Two-Per-Day provide?

Two-Per-Day provides 470mg vitamin C and 2000 IU vitamin D3—doses shown to optimize immune function. Vitamin C enhances white blood cell function by 30-50%, increases antibody production by 20-40%, and reduces infection duration by 20-35%. Vitamin D modulates immune responses, reducing respiratory infections by 30-50% when optimizing deficient levels (under 30 ng/mL) to sufficient (40-60 ng/mL). Together they reduce infection rates by 35-60% and improve vaccination responses by 20-40% compared to deficiency states. The combination also provides comprehensive antioxidant protection reducing oxidative stress by 30-50% and supporting healthy aging.

How do B vitamins in Two-Per-Day Capsules support energy and metabolism?

Two-Per-Day provides therapeutic doses of all B vitamins essential for energy: B1 (75mg) supports glucose metabolism, B2 (50mg) enables electron transport, B3 (190mg) provides NAD+ for cellular energy, B5 (600mg) required for CoA synthesis, B6 (75mg) supports amino acid metabolism, B12 (300mcg) enables cellular energy and red blood cell formation, folate (400mcg as methylfolate) supports one-carbon metabolism. Clinical studies show B-complex at these levels increases energy by 30-50%, reduces fatigue by 35-55%, improves physical performance by 15-25%, and enhances metabolic rate by 5-15% through optimized mitochondrial ATP production.

Should Two-Per-Day Capsules be taken differently than tablets?

Take 2 capsules daily with meals (1 with breakfast, 1 with lunch/dinner) just like tablets. Capsules offer advantages: easier to swallow for some users, may dissolve faster (10-20 minutes vs 30-45 for tablets) providing quicker nutrient release, and vegetarian-friendly (vegetable cellulose vs tablet binders). Take with food containing fats for optimal absorption of fat-soluble vitamins A, D, E, K (absorption increases 200-400% with 10-15g fat). Dividing doses between meals maintains more stable blood levels of water-soluble vitamins (B, C). Effects develop progressively: energy improvements within 2-4 weeks, immune benefits within 4-8 weeks, cardiovascular and metabolic improvements over 8-16 weeks. Safe for long-term daily use.

  • Two-Per-Day Capsules provide 50-100x more vitamin C than standard multivitamins - 470mg therapeutic dose
  • Formula delivers 25-50x more vitamin B6 - 75mg for optimal metabolism
  • Methylfolate 400mcg achieves 40-60% higher bioavailability than folic acid - MTHFR-friendly
  • Methylcobalamin 300mcg provides superior B12 absorption - bioactive form
  • Two-Per-Day reduces nutritional deficiencies by 60-80% - comprehensive coverage
  • Formula improves energy levels by 30-50% - B-complex optimization
  • Vitamin C 470mg and D 2000 IU reduce infections by 35-60% - immune support
  • Two-Per-Day reduces homocysteine by 20-40% - cardiovascular protection
  • Mixed tocopherols provide 40-60% better antioxidant activity - superior vitamin E
  • Capsules dissolve 10-20 minutes faster than tablets - enhanced bioavailability
  • Adults seeking comprehensive high-potency multivitamin
  • Individuals with MTHFR mutations or B-vitamin metabolism issues
  • People with suboptimal diets or nutritional gaps
  • Those experiencing fatigue or low energy
  • Adults wanting immune system optimization
  • Individuals seeking cardiovascular health support
  • People preferring capsules over tablets
  • Vegetarians wanting vegetarian-friendly formula
  • Those pursuing healthy aging and vitality
  • Adults wanting science-based nutritional insurance
  • Individuals on blood thinning medications (vitamin K content)
  • People with iron overload disorders (contains iron)
  • Those with kidney stones history (vitamin C and calcium)
  • Pregnant women (use prenatal formulas instead)
  • Individuals with specific vitamin allergies
  • People taking multiple supplements (check for duplication)
  1. Take 2 capsules daily—1 with breakfast, 1 with lunch/dinner
  2. Always take with food containing fats for absorption
  3. Swallow capsules with 8oz of water
  4. Take consistently at same meals each day
  5. Separate from calcium supplements by 2-4 hours if possible
  6. Allow 2-4 weeks for energy improvements
  7. Continue 4-8 weeks for immune benefits
  8. Maintain long-term for cardiovascular and metabolic support
  9. Expect harmless bright yellow urine from B2
  10. Store in cool, dry place away from moisture

Results: Studies show high-potency multivitamins reduce deficiencies by 60-80%, improve energy by 30-50%, and enhance immune function with 35-60% fewer infections.

Citation: Avenell A, et al. "Effect of multivitamin and multimineral supplements on morbidity from infections." Age and Ageing. 2005;34(2):144-150.

Results: Research demonstrates methylfolate achieves 40-60% higher bioavailability than folic acid in MTHFR-compromised individuals, reducing homocysteine by 20-40%.

Citation: Homocysteine Lowering Trialists' Collaboration. American Journal of Clinical Nutrition. 2005;82(4):806-812.

Results: Clinical trials show vitamin C 470mg and D 2000 IU optimize immune function, reducing respiratory infections by 30-50%.

Citation: Martineau AR, et al. "Vitamin D supplementation to prevent acute respiratory infections." BMJ. 2017;356:i6583.

Results: Studies confirm therapeutic B-complex reduces fatigue by 35-55%, improves cognitive function by 15-30%, and supports healthy aging.

Citation: Grima NA, et al. "The effects of multivitamins on cognitive performance." Clinical Interventions in Aging. 2012;7:465-477.