Why Take Nattokinase Supplements

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What is nattokinase and where does it come from?

Nattokinase is proteolytic enzyme produced during fermentation of soybeans to make natto, traditional Japanese food. The enzyme is produced by Bacillus subtilis bacteria during fermentation. Nattokinase has fibrinolytic activity, meaning it helps break down fibrin (protein involved in blood clot formation). Japanese populations consuming natto regularly have lower cardiovascular disease rates, leading to research on nattokinase's health benefits including blood pressure reduction, improved circulation, and cardiovascular protection.

How does nattokinase support cardiovascular health?

Nattokinase supports cardiovascular system through multiple mechanisms including fibrinolytic activity helping dissolve blood clots and prevent excessive clotting, blood pressure reduction through various pathways, improved blood flow and circulation, anti-atherosclerotic effects, and anti-inflammatory properties. Research shows nattokinase may benefit conditions like hypertension, chronic venous insufficiency, and cardiovascular disease risk. It provides natural support for healthy blood flow and clot prevention.

Can nattokinase lower blood pressure?

Clinical studies demonstrate nattokinase can reduce blood pressure in hypertensive individuals. Randomized controlled trial showed significant reductions in both systolic and diastolic blood pressure with nattokinase supplementation. Mechanisms include improved endothelial function, enhanced nitric oxide production, reduced arterial stiffness, and ACE inhibitor-like activity. Typical doses of 2000-4000 FU (fibrinolytic units) daily show blood pressure benefits. Effects are modest but clinically relevant, comparable to some lifestyle interventions.

Does nattokinase help with varicose veins and venous insufficiency?

Research suggests nattokinase and related supplements may benefit chronic venous insufficiency and varicose veins by improving circulation, reducing inflammation in vessel walls, supporting healthy blood flow, and potentially reducing venous pooling. While some studies show benefits, more research needed on nattokinase specifically for venous conditions. Often combined with other natural approaches like Pycnogenol (shown effective in clinical trials), horse chestnut, and compression therapy for comprehensive venous health support.

What is the proper dosage and are there safety concerns with nattokinase?

Typical nattokinase doses are 2000-4000 FU (fibrinolytic units) daily, usually taken on empty stomach for best absorption. Safety profile is generally good but important considerations include avoiding if on blood thinners (warfarin, heparin) due to additive effects, discontinuing 2 weeks before surgery due to bleeding risk, using caution with antiplatelet drugs (aspirin, clopidogrel), and monitoring if taking blood pressure medications. People with bleeding disorders should avoid nattokinase. Always inform healthcare providers about nattokinase use.

  • Nattokinase is fibrinolytic enzyme from fermented soybeans helping dissolve blood clots naturally
  • Japanese consuming natto regularly have lower cardiovascular disease rates suggesting protective effects
  • Nattokinase reduces blood pressure significantly in randomized controlled trials
  • Nattokinase improves circulation and blood flow through multiple cardiovascular mechanisms
  • Nattokinase has anti-atherosclerotic effects potentially reducing plaque formation
  • Nattokinase may benefit venous insufficiency and varicose veins through improved circulation
  • Nattokinase provides anti-inflammatory benefits to cardiovascular system
  • 2000-4000 FU daily is typical dose showing cardiovascular benefits in studies
  1. Standard dosing: Take 2000-4000 FU nattokinase daily
  2. On empty stomach: Take at least 30 minutes before meals or 2 hours after for best absorption
  3. Timing options: Can take once daily or split into 2 doses (morning and evening)
  4. Start lower: Begin with 2000 FU daily, increase to 4000 FU if needed after 2-4 weeks
  5. Check FU content: Look for products standardized to fibrinolytic units (FU), not just mg
  6. Inform healthcare providers: Tell all doctors about nattokinase use, especially before surgery
  7. Monitor if on medications: Work with healthcare provider if taking blood pressure or other cardiovascular medications
  8. Discontinue before surgery: Stop nattokinase 2 weeks before any surgical procedure
  9. Avoid with blood thinners: Do not combine with warfarin or other anticoagulants without medical supervision
  10. Long-term use: Safe for continuous supplementation in appropriate individuals
  11. Comprehensive approach: Combine with healthy diet, exercise, and other cardiovascular support measures
  • People with hypertension seeking natural blood pressure support
  • Individuals concerned about blood clots or excessive clotting tendency
  • Those with cardiovascular disease risk wanting natural prevention strategies
  • People with chronic venous insufficiency or varicose veins
  • Individuals with poor circulation or sluggish blood flow
  • Those with family history of cardiovascular disease or stroke
  • People wanting to support healthy aging and longevity like Japanese populations
  • Individuals seeking natural fibrinolytic support for cardiovascular health
  • People on blood thinners (warfarin, heparin, NOACs) - nattokinase has additive anticoagulant effects
  • Those on antiplatelet medications (aspirin, clopidogrel) - increased bleeding risk when combined
  • Individuals with bleeding disorders (hemophilia, von Willebrand disease)
  • People scheduled for surgery - discontinue 2 weeks before due to bleeding risk
  • Those with active bleeding (ulcers, recent hemorrhagic stroke)
  • Pregnant or breastfeeding women - insufficient safety data
  • Individuals with very low blood pressure - nattokinase may lower it further
  • People allergic to soy - nattokinase is derived from fermented soybeans

Results: Clinical research shows Pycnogenol beneficial for chronic venous insufficiency and varicose veins. Studies demonstrate improvements in venous symptoms, edema, and quality of life.

Citation: Belcaro G. Int J Angiol. [Pycnogenol, Antistax, and Stocking in Chronic Venous Insufficiency]

Results: Research demonstrates Pycnogenol benefits postpartum varicose veins. Supplementation showed improvements compared to elastic compression in 12-month follow-up study.

Citation: Belcaro G, et al. [Postpartum Varicose Veins: Pycnogenol or Elastic Compression]

Results: Randomized controlled trial shows nattokinase has effects on blood pressure reduction. Study demonstrated significant decreases in both systolic and diastolic blood pressure with nattokinase supplementation.

Citation: Kim JY, et al. Hypertens Res. 2008 [Effects of nattokinase on blood pressure]