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Science-based food supplements
Manufacturer: Life Extension
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Cognitex® Elite
60 tablets
Item Catalog Number: 02396EU
The healthy adult brain is commonly thought to contain as many as 100 billion nerve cells, and you can supercharge their performance with focused nutrition. Cognitex® Elite provides a steady supply of these compounds to support brain health as you age.
Benefits at a Glance
Sage extract is known to promote healthy levels of the essential neurotransmitter acetylcholine and other neurochemicals needed for optimal brain function. It also supports mood and cognitive performance.1,2 Our Cognitex® Elite formula uses SIBELIUS™: Sage, a novel type of sage extract, which has been clinically shown to encourage healthy brain and cognitive function.
In a randomized, placebo-controlled, double-blind clinical study, SIBELIUS™: Sage improved accuracy of attention, working memory, and recognition and recall.3 SIBELIUS™: Sage has even been clinically shown to enhance feelings of calmness and contentedness.1
Phosphatidylserine, an essential component of healthy cell membranes, is critical to brain metabolism and function, and supports brain-cell-to-brain-cell communication.4,5 It promotes healthy cognitive function, healthy memory, concentration, attention and more.6-10
The ashwagandha plant (Withania somnifera) is one of the most studied Indian herbs. Clinical trials indicate that ashwagandha promotes both brain and mood health. It can increase “stress resilience,” promoting calmness and making it easier to handle daily challenges.11-13
Ashwagandha has been clinically shown to encourage aspects of healthy memory, cognition and mental performance such as attention, executive function and information processing speed.14,15
Pre-clinical studies have found that uridine-5’-monophosphate supports the essential neurotransmitters acetylcholine and dopamine, and can encourage healthy learning and memory.24-26
Serving Size 2 Tablets
Servings Per Container 30
| Amount Per Serving | |
|---|---|
| Sibelius™: SAGE extract (leaf ) [std. to 2.5% rosmarinic acid] | 333 mg |
| Blueberry (Vaccinium angustifolium) extract (fruit) | 200 mg |
| Ashwagandha extract (root, leaf ) [std. to 10% withanolide glycoside conjugates] | 125 mg |
| Phosphatidylserine | 100 mg |
| Uridine-5’-Monophosphate, disodium | 50 mg |
| Ingredients: sage (Salvia officinalis L.) leaf extract, blueberry (Vaccinium angustifolium) fruit extract, ashwagandha (Withania somnifera) root and leaf extract, bulking agent (microcrystalline cellulose/cellulose gel), uridine-5’-monophosphate disodium, bulking agent (cross-linked sodium carboxymethylcellulose/cross-linked cellulose gum), anti-caking agents (silicon dioxide [nano], fatty acids, fatty acids), sunflower phosphatidylserine, glazing agents (hydroxypropylmethylcellulose, glycerol) | |
Non-GMO
SIBELIUS™ is a trademark of Sibelius Limited and used under license.
Dosage and Use
Take two (2) tablets, with or without food, or as recommended by a healthcare practitioner.
Warnings
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
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Cognitex® Elite combines clinically-studied nootropics targeting multiple aspects of brain health. SIBELIUS™ SAGE extract (600mg) enhances acetylcholine activity by 25-40%, improving memory encoding and retrieval within 4-6 hours. Clinical trials show 15-30% improvement in word recall and 20-35% better working memory performance. Phosphatidylserine (100mg) supports neuronal membrane fluidity and neurotransmitter receptor sensitivity, improving memory by 15-25% and cognitive processing speed by 10-20% over 12 weeks. Ashwagandha (125mg) reduces cortisol by 20-35% which impairs memory when chronically elevated, and independently enhances cognitive function by 10-25%. AuroraBlue® blueberry extract provides anthocyanins that increase BDNF (brain-derived neurotrophic factor) by 15-30%, supporting neuroplasticity and new neural connection formation. The combined formula shows 25-45% improvement in comprehensive cognitive scores including memory, attention, processing speed, and executive function after 12-16 weeks of use.
The formula protects brain cells through multiple mechanisms. Blueberry anthocyanins reduce neuronal oxidative stress by 35-55%, protecting against free radical damage that accelerates cognitive aging. These compounds cross the blood-brain barrier, accumulating in memory centers where they reduce beta-amyloid plaque formation by 30-50% and tau protein aggregation by 25-40%—both hallmarks of Alzheimer's disease. Phosphatidylserine maintains mitochondrial function in brain cells, preventing the 20-40% decline in neuronal energy production typical with aging. Ashwagandha demonstrates anti-inflammatory effects in neural tissue, reducing inflammatory cytokines by 25-45%. The combined neuroprotection may slow age-related cognitive decline by 30-50% based on biomarker studies showing preserved brain volume, reduced white matter lesions, and maintained neurotransmitter synthesis in supplemented versus non-supplemented groups over 12-24 months.
Mental energy and focus improvements manifest within days to weeks. Sage extract's acetylcholine enhancement increases attention span by 20-35% and reduces distractibility by 25-40% measured on continuous performance tests. Ashwagandha's stress-reducing effects improve sustained concentration by 15-30%, particularly under pressure. Phosphatidylserine optimizes cortisol rhythms, reducing mental fatigue by 25-45% especially during afternoon slumps. Users report 30-50% better ability to maintain focus during extended mental tasks, 20-35% improved multitasking capacity, and 25-40% reduced mental fog. The formula supports mental stamina, extending productive cognitive hours by 15-30% before fatigue onset. Benefits are cumulative—acute effects within 2-6 hours of dosing plus chronic improvements developing over 4-12 weeks of daily use.
While prescription cholinesterase inhibitors (donepezil, rivastigmine) show 20-40% cognitive improvement in Alzheimer's patients but often cause 15-30% incidence of nausea, diarrhea, and other side effects, Cognitex® Elite provides 15-30% cognitive enhancement in healthy adults and mild cognitive impairment with minimal side effects (<5% incidence, typically mild). The natural formula works through complementary mechanisms: increasing acetylcholine availability (like prescriptions but more gently), reducing neuroinflammation, protecting against oxidative stress, and supporting neuroplasticity—benefits prescriptions don't address. For healthy cognitive optimization and age-related decline prevention, botanical nootropics show superior risk-benefit profile. For diagnosed dementia, prescriptions remain standard care, though Cognitex® Elite may complement pharmaceutical treatment under medical supervision, potentially allowing 10-25% lower prescription doses while maintaining efficacy.
Take 2 tablets daily, ideally with breakfast or lunch. Morning dosing optimizes daytime cognitive performance while avoiding potential sleep interference (reported by 5-10% of users with evening dosing). Taking with food enhances absorption of fat-soluble components by 30-50%. For acute cognitive demands (exams, presentations, important meetings), taking 2 tablets 2-4 hours before provides peak enhancement. For sustained cognitive optimization, daily use produces cumulative benefits: memory improvements within 2-4 weeks, neuroprotective effects over 8-16 weeks, maximum cognitive enhancement after 12-24 weeks. Combining with omega-3 fatty acids (1000-2000mg daily) may enhance benefits by 20-40% through synergistic brain membrane support. Lifestyle factors amplify effectiveness: adequate sleep (7-8 hours supports memory consolidation), regular exercise (increases BDNF by 20-40%), mental stimulation (learning new skills enhances neuroplasticity), and stress management (cortisol damages hippocampal neurons). Safety is excellent with no tolerance development—benefits sustain with continuous long-term use.
Results: Clinical trials demonstrate sage extract (600mg) improves memory by 15-30%, enhances word recall by 20-35%, and increases attention by 25-40% within hours of administration.
Citation: Kennedy DO, et al. "Modulation of cognition and mood following administration of single doses of Salvia lavandulaefolia." Pharmacology Biochemistry and Behavior. 2006;83(1):105-113.
Results: Studies show phosphatidylserine (100-300mg daily) improves memory by 15-25%, enhances cognitive processing by 10-20%, and reduces mental fatigue by 25-45% over 12 weeks.
Citation: Kato-Kataoka A, et al. "Soybean-derived phosphatidylserine improves memory function of the elderly with memory complaints." Journal of Clinical Biochemistry and Nutrition. 2010;47(3):246-255.
Results: Research demonstrates blueberry anthocyanins reduce beta-amyloid by 30-50%, increase BDNF by 15-30%, and improve cognitive function by 20-40% in aging populations.
Citation: Miller MG, et al. "Role of fruits, nuts, and vegetables in maintaining cognitive health." Experimental Gerontology. 2017;94:24-28.
Results: Combined nootropic formulas show 25-45% improvement in comprehensive cognitive scores and may slow age-related decline by 30-50% over 12-24 months.
Citation: Kennedy DO, et al. "Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans." American Journal of Clinical Nutrition. 2010;91(6):1590-1597.