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Low-Dose Vitamin K2 (MK-7) EU

Category: Vitamin K

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Helps maintain bone density

  • Plays a critical role in maintaining healthy bone density

  • Is required by calcium-regulating proteins in the arteries

  • The menaquinone-7 form of vitamin K2 is not metabolized quickly by the liver

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Low-Dose Vitamin K2

45 mcg, 90 softgels

Item Catalog Number: 01936EU

NON GMO ProductAn abundance of human clinical data reveals that vitamin K plays a critical role in maintaining healthy bone density by facilitating the transport of calcium from the bloodstream into the bone.1-5 Vitamin K is also required by calcium-regulating proteins in the arteries. Matrix Gla-protein (MGP) is a vitamin K-dependent protein, and it must be carboxylated to function properly. Poor vitamin K status leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification.6,7 Since MGP is a potent local inhibitor of arterial calcification, MGP is important in relation to the health of the entire cardiovascular system. Without adequate vitamin K, calcium in the blood can bind to the arterial wall resulting in calcification.8,9 As people age, even a subclinical vitamin K deficiency can pose risks to the vascular system. Poor vitamin K status also results in increased circulating levels of undercarboxylated osteocalcin that is shown to be associated with increased bone loss in postmenopausal women.10,11

Vitamin K2 (menaquinones) is found in meat, eggs, and dairy products and is also made by bacteria in the human gut, which provides a certain amount of the human vitamin K requirement.20 Human studies show that vitamin K2 is up to ten times more bioavailable than K1. Vitamin K2 remains biologically active in the body far longer than K1. For instance, K1 is rapidly cleared by the liver within eight hours, whereas measurable levels of K2 (MK-7) have been detected 72 hours after ingestion.5

The Rotterdam Heart Study, a large-scale, well-controlled clinical trial that tracked 4,800 participants for seven years, revealed that participants who ingested the greatest quantities of vitamin K2 in their diet experienced a better cardiovascular condition than people who ingested the least.13 High intakes of vitamin K2 also corresponded to less calcium deposition in the aorta, whereas participants who ingested less K2 were more likely to show moderate or severe calcification. Animal studies suggest vitamin K intake not only blocks the progress of further calcium accumulation, but also induces 37% regression of preformed arterial calcification.14,15

Low-Dose Vitamin K2 contains the menaquinone-7 form of vitamin K2, which is not metabolized quickly by the liver, thereby making it available to provide a more consistent supply of vitamin K to the body.

Supplement Facts

Serving Size 1 softgel

Amount Per Serving
Vitamin K2 (as all-trans menaquinone-7) 45 mcg
Ingredients: Medium chain triglycerides, capsule (gelatine), humectant (glycerol), menaquinone (vitamin K2), purified water, roasted carob fruit extract


Non-GMO


Dosage and Use

Take one (1) softgel daily with food, or as recommended by a healthcare practitioner.


Caution

If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

  1. J Bone Miner Metab. 2001;19(3):146-9.

  2. Osteoporos Int. 2007 Jul;18(7):963-72.

  3. J Bone Miner Res. 2007 Apr;22(4):509-19.

  4. Br J Nutr. 2009 Oct;102(8):1171-8.

  5. Blood. 2007 Apr 15;109(8):3279-83.

  6. Atherosclerosis. 2012 Dec;225(2):397-402.

  7. Adv Nutr. 2012 Mar 1;3(2):166-73.

  8. Thromb Haemost. 2008 Oct;100(4):593-603.

  9. Clin J Am Soc Nephrol. 2008 Sep;3(5):1504-10.

  10. Vitam Horm. 2008;78:393-416.

  11. Curr Drug Saf. 2006 Jan;1(1):87-97.

  12. Clin Calcium. 2007 Nov;17(11):1663-72.

  13. J Nutr. 2004 Nov;134(11):3100-5.

  14. Blood. 2007 Apr 1;109(7):2823-31.

  15. J Vasc Res. 2003 Nov-Dec;40(6):531-7.

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Scientific Sources

Frequently Asked Questions about Low-Dose Vitamin K2 (MK-7)

What is vitamin K2 and how does it differ from vitamin K1?

Vitamin K exists in two primary forms with distinct biological roles. Vitamin K1 (phylloquinone) is found abundantly in green leafy vegetables and is primarily involved in blood clotting. Your liver uses K1 to produce clotting factors that prevent excessive bleeding. Vitamin K2 (menaquinone), on the other hand, is found in fermented foods and animal products and plays crucial roles beyond clotting - particularly in calcium metabolism and cardiovascular health.

The K2 form, specifically MK-7 (menaquinone-7), has several advantages over both K1 and shorter-chain K2 forms like MK-4. MK-7 has a much longer half-life in your bloodstream - remaining active for 72 hours compared to just 1-2 hours for K1 and 6-8 hours for MK-4. This extended duration means MK-7 provides more sustained activation of vitamin K-dependent proteins throughout your body.

The most important K2-dependent proteins include osteocalcin (which helps bind calcium to bone matrix) and matrix Gla-protein or MGP (which prevents calcium from depositing in soft tissues like arteries). Without adequate K2, these proteins remain inactive and cannot perform their critical functions, potentially leading to both reduced bone density and increased arterial calcification.

How does vitamin K2 support bone and cardiovascular health?

Vitamin K2's role in bone health centers on activating osteocalcin, a protein produced by bone-building cells. Once activated, osteocalcin binds calcium ions and incorporates them into the bone matrix. Studies demonstrate that vitamin K2 supplementation increases the percentage of carboxylated osteocalcin, improves bone mineral density, and reduces fracture risk.

The cardiovascular benefits are equally important. Matrix Gla-protein (MGP) is produced by cells in arterial walls and, when activated by K2, prevents calcium from depositing in arterial tissue. Studies have found that people with higher K2 intake have less arterial calcification and better cardiovascular outcomes.

Who should consider vitamin K2 supplementation?

Postmenopausal women concerned about bone health should prioritize K2, as bone loss accelerates significantly after menopause. Anyone taking high-dose vitamin D or calcium supplements should consider K2, as it helps direct calcium appropriately. People following plant-based diets may have suboptimal K2 status since K2 is primarily found in animal products and fermented foods.

Are there any interactions or precautions with vitamin K2?

The most important consideration is interaction with warfarin (Coumadin). If you're on warfarin, you should not take vitamin K supplements without medical supervision. However, newer anticoagulants don't interact with vitamin K in the same way. Vitamin K2 appears very safe with no established upper intake limit.

How should I take vitamin K2 for optimal results?

Vitamin K2 is fat-soluble, so take it with a meal containing dietary fat. Consistency is important for maintaining stable activation of K2-dependent proteins. For maximum benefit, combine K2 with vitamin D and adequate calcium intake. Allow adequate time to assess benefits - effects on bone density occur gradually over months to years.

  • MK-7 (menaquinone-7) has 72-hour half-life providing sustained activity
  • Vitamin K2 activates osteocalcin which binds calcium to bone matrix
  • MK-7 supplementation increases carboxylated osteocalcin by 40-50%
  • K2 activates matrix Gla-protein (MGP) preventing arterial calcification
  • Studies show MK-7 improves bone mineral density and reduces fracture risk
  • Higher K2 intake correlates with 50% lower cardiovascular risk in long-term studies
  • Low-dose MK-7 directs calcium to bones and away from soft tissues
  • Three-year studies demonstrate K2 significantly reduces age-related bone loss
  • MK-7 works synergistically with vitamin D and calcium for optimal bone support
  • The low-dose formulation is well-tolerated with no significant adverse effects

Who Should Consider Low-Dose Vitamin K2?

  • Postmenopausal women concerned about bone density
  • Adults taking vitamin D or calcium supplements
  • People following plant-based diets with limited K2 intake
  • Older adults experiencing age-related bone loss
  • Individuals interested in cardiovascular health support
  • Those seeking to optimize calcium utilization
  • People concerned about arterial calcification
  • Adults committed to long-term bone health maintenance
  • Individuals wanting to support vitamin K-dependent protein activation
  • Those seeking well-researched bone and heart health nutrients

Who Should Consult Healthcare Provider?

  • People taking warfarin (Coumadin) or similar blood thinners
  • Individuals on any anticoagulant medication
  • Those with blood clotting disorders
  • People scheduled for surgery
  • Pregnant or breastfeeding women
  • Anyone with concerns about vitamin K interactions

How to Use Low-Dose Vitamin K2

  1. Take with meal containing dietary fat - enhances absorption
  2. Maintain daily consistency for stable protein activation - same time each day
  3. Combine with vitamin D and calcium - synergistic bone support
  4. Do not take if on warfarin without medical supervision - critical interaction
  5. Inform healthcare provider about K2 use - especially if taking medications
  6. Consider taking with dinner - typically contains most fat
  7. Allow 6-12 months for full benefits - bone changes take time
  8. Continue long-term for sustained support - ongoing bone and vascular health
  9. Store in cool, dry place - maintains potency
  10. Track bone density if possible - objective measure of effectiveness

Results: Three-year study found postmenopausal women taking 180 mcg daily MK-7 had significantly improved bone strength and 50% less age-related decline in bone mineral density compared to placebo.

Citation: Knapen MH, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013.

Results: MK-7 supplementation increased percentage of carboxylated osteocalcin by 40-50% within 6-12 weeks.

Citation: Theuwissen E, et al. Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status. Br J Nutr. 2012.

Results: Population study found highest K2 intake associated with 57% lower risk of cardiovascular mortality over 10 years.

Citation: Geleijnse JM, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease. J Nutr. 2004.

Results: Long-term K2 supplementation reduced inactive undercarboxylated MGP by 50%.

Citation: Cranenburg EC, et al. Vitamin K intake and status are low in hemodialysis patients. Kidney Int. 2012.