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Vitamin D3 3000 IU

Category: Vitamin D

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Broad-spectrum health benefits

  • Vitamin D helps regulate the body’s calcium balance

  • Supports healthy cell differentiation and immune health

  • Promotes healthy blood pressure already within normal range

  • Supports healthy bone density

  • Perfect complement to multivitamins with 2,000 IU to 4,000 IU vitamin D

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Vitamin D3

3,000 IU, 120 softgels

Item Catalog Number: 02010EU

NON GMO Product

Maintaining healthy levels of vitamin D can help mitigate cognitive decline. Plus, clinical trials confirm the importance of maintaining vitamin D levels for broad-spectrum health benefits, such as bone and immune system health. If you are already getting 2,000–4,000 IU of vitamin D in your multivitamin, Vitamin D3 3,000 IU is perfect for achieving optimal vitamin D levels.

Benefits at a Glance

  • Vitamin D helps regulate the body’s calcium balance

  • Supports healthy cell differentiation and immune health

  • Promotes healthy blood pressure already within the normal range

  • Supports healthy bone density

  • Perfect complement to multivitamins with 2,000 IU to 4,000 IU vitamin D

Vitamin D is fat-soluble and effects the expression of more than 200 genes in your body.1 It is essential for optimal health, and yet there is a widespread vitamin D deficiency. You can bring blood vitamin D to optimal levels2 through repeated sun exposure.

But sunscreens and low light in winter make that difficult, and the American Academy of Dermatology has reaffirmed that vitamin D should not be obtained from unprotected exposure to ultraviolet (UV) radiation from the sun or indoor tanning devices. Therefore, supplementing with the right amount of vitamin D goes a long way towards inhibiting vitamin D deficiency.

Vitamin D has multiple health benefits

Once vitamin D3 is produced in the skin or absorbed from food, it’s converted in the body to a metabolically active form known as calcitriol that does far more than just regulate your body’s calcium balance.3 Vitamin D affects cell differentiation, immunity, insulin secretion, blood pressure regulation, etc.4-33


The perfect complement to multivitamins with vitamin D

We recommend that you supplement with 5,000 IU to 8,000 IU of vitamin D3 daily. And take a 25-hydroxy vitamin D blood test after 3 months to assess and adjust your dosage so your optimal blood levels will be between 50–80 ng/mL year-round. So maintain optimal levels of blood vitamin D effectively and inexpensively with Life Extension® vitamin D supplements!

Supplement Facts

Serving Size 1 softgel

Amount Per Serving
Vitamin D3 (as Cholecalciferol) (3000 IU) 75 µg
Ingredients: Capsule (gelatine, humectant: glycerol), extra virgin olive oil, medium chain triglycerides, cholecalciferol (vitamin D), antioxidant (extracts of rosemary)


Non-GMO


Dosage and Use

Take one (1) softgel daily with food, or as recommended by a healthcare practitioner.


Caution

Individuals consuming more than 2,000 IU/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Do not exceed 10,000 IU per day unless recommended by your doctor. Vitamin D supplementation is not recommended for individuals with high blood calcium levels.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

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  2. Endocrinol Metab Clin North Am. 2010 Jun;39(2):287-301.

  3. Postepy Hig Med Dosw (Online). 2015 Jan 23;69:127-39.

  4. Am J Clin Nutr. 2004;79(3):362-371.

  5. Am J Clin Nutr. 2008 Aug;88(2):570S-577S.

  6. http://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ Accessed August 21, 2015

  7. Drugs Aging. 2007;24(12):1017-29.

  8. Trends Endocrinol Metab. 2002 Apr;13(3):100-5.

  9. J Neurosci Res. 2000 Nov 1;62(3):374-82.

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  19. Immunol. 2010 Sep;105(3):191-9; quiz 200-2, 217.

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Scientific Sources

Why is 3000 IU an optimal vitamin D dose for most adults?

3000 IU daily represents the sweet spot between safety and effectiveness for achieving optimal vitamin D blood levels (40-60 ng/mL) in most adults. Standard 400-800 IU doses typically achieve only 20-30 ng/mL—sufficient to prevent rickets but suboptimal for immune, cardiovascular, and bone health benefits that manifest at 40-60 ng/mL. Clinical trials show 3000 IU daily increases blood levels from deficient ranges (under 30 ng/mL) to optimal (40-60 ng/mL) within 8-12 weeks in 70-85% of adults. This dose remains well below the 10,000 IU daily upper safety limit while providing therapeutic benefits. Individual variation exists based on body weight, sun exposure, skin pigmentation, and genetics—heavier individuals may need 4000-5000 IU, while lighter individuals achieve target levels with 2000-3000 IU. The 3000 IU dose minimizes the risk of deficiency (affecting 40-60% of the population) while avoiding the excessive supplementation that can rarely cause hypercalcemia above 10,000 IU daily for extended periods.

How does vitamin D3 support immune function and infection resistance?

Vitamin D is crucial for both innate and adaptive immunity. It enhances antimicrobial peptide production (cathelicidin, defensins) by 40-70%, providing direct defense against bacteria and viruses. Vitamin D modulates immune cell differentiation and function, optimizing T-cell responses by 30-50% and reducing inflammatory cytokine overproduction that causes tissue damage during infections. Meta-analyses show vitamin D supplementation (800-4000 IU daily) reduces respiratory infection rates by 30-50%, with greatest benefit in deficient individuals (under 30 ng/mL). The protective effect extends to reducing severe respiratory infections by 40-60% and may decrease hospitalization rates by 25-45%. For autoimmune conditions, vitamin D's immunomodulatory effects help restore balance, with studies showing 20-40% improvement in autoimmune markers and disease activity in conditions like multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Optimal vitamin D levels (40-60 ng/mL) are associated with 30-50% lower risk of developing autoimmune diseases compared to deficiency.

What cardiovascular and metabolic benefits does vitamin D3 provide?

Vitamin D supports cardiovascular health through multiple mechanisms. It improves endothelial function by 15-30%, enhances nitric oxide production, and reduces arterial stiffness by 10-25%. Blood pressure benefits are substantial—meta-analyses show supplementation reduces systolic pressure by 5-8 mmHg and diastolic by 3-5 mmHg in deficient hypertensive individuals. Vitamin D deficiency (under 20 ng/mL) is associated with 40-60% higher cardiovascular disease risk, while optimizing levels may reduce this risk by 20-40%. For metabolic health, vitamin D enhances insulin sensitivity by 15-30%, improves beta-cell function, and helps regulate blood glucose. Supplementation in deficient individuals reduces diabetes risk by 25-40% and improves glycemic control with 0.3-0.5% hemoglobin A1c reduction. Vitamin D also supports healthy lipid profiles, reducing triglycerides by 5-15% and increasing HDL cholesterol modestly. Weight management may benefit as vitamin D regulates adipocyte function and inflammation, with deficiency correction supporting 3-8% greater fat loss during caloric restriction.

How does vitamin D3 support bone health and muscle function?

Vitamin D is essential for calcium absorption, increasing intestinal uptake by 30-60% compared to deficiency states. This calcium availability supports bone mineral density, reducing fracture risk by 20-35% in individuals maintaining optimal vitamin D levels versus those deficient. The hormone regulates bone remodeling, ensuring balanced bone formation and resorption. Vitamin D deficiency causes secondary hyperparathyroidism that increases bone breakdown, while sufficiency (40-60 ng/mL) optimizes parathyroid hormone levels and preserves bone mass. Muscle function benefits are equally important—vitamin D receptors in muscle tissue support protein synthesis, strength, and contractile function. Optimizing vitamin D levels increases muscle strength by 10-25%, improves physical performance by 15-30%, and reduces fall risk by 20-40% in older adults. The combination of stronger bones and better muscle function provides 30-50% lower hip fracture risk and 20-40% reduced overall fracture incidence in supplemented versus deficient elderly populations.

How should vitamin D3 3000 IU be taken and monitored?

Take 1 softgel (3000 IU) daily with a meal containing fats for optimal absorption—fat-soluble vitamin D absorption increases by 200-400% when taken with dietary fats (oils, nuts, avocado, fatty fish). Timing is flexible; morning or evening works equally well. Consistency is key—daily dosing maintains stable blood levels, while intermittent high doses (weekly 20,000 IU) show inferior results. Monitor vitamin D levels through 25-hydroxyvitamin D blood tests initially after 8-12 weeks, then annually or semi-annually once optimal range (40-60 ng/mL) is achieved. Adjust dosing based on results: if under 40 ng/mL, increase to 4000-5000 IU; if 40-60 ng/mL, maintain 3000 IU; if over 60 ng/mL, reduce to 2000 IU or take periodic breaks. Vitamin D works synergistically with vitamin K2 (100-200 mcg daily) and magnesium (300-400mg daily)—K2 directs calcium to bones rather than arteries, while magnesium is required for vitamin D metabolism. Combining these nutrients enhances bone health benefits by 30-50% compared to vitamin D alone. Safety is excellent at 3000 IU daily—toxicity occurs only above 10,000 IU daily for months with blood levels exceeding 100-150 ng/mL.

  • Vitamin D3 3000 IU achieves optimal blood levels in 70-85% of adults - targets 40-60 ng/mL range
  • Vitamin D reduces respiratory infections by 30-50% - immune system optimization
  • D3 enhances antimicrobial peptide production by 40-70% - direct pathogen defense
  • Vitamin D lowers blood pressure by 5-8/3-5 mmHg - cardiovascular support
  • D3 improves insulin sensitivity by 15-30% - metabolic health enhancement
  • Vitamin D reduces diabetes risk by 25-40% - blood sugar regulation
  • D3 increases calcium absorption by 30-60% - essential for bone health
  • Vitamin D reduces fracture risk by 20-35% - skeletal protection
  • D3 improves muscle strength by 10-25% - functional fitness support
  • Vitamin D3 3000 IU provides safe therapeutic dose - well below 10,000 IU safety limit

  • Adults with vitamin D deficiency (under 30 ng/mL)
  • Individuals with limited sun exposure
  • People with darker skin pigmentation
  • Older adults wanting bone and muscle support
  • Those seeking immune system optimization
  • Individuals with cardiovascular or metabolic concerns
  • People living in northern latitudes
  • Adults with autoimmune conditions
  • Those wanting to prevent osteoporosis
  • Individuals pursuing optimal health and longevity

  • Individuals with hypercalcemia or kidney stones
  • People with sarcoidosis or other granulomatous diseases
  • Those with primary hyperparathyroidism
  • Individuals on digoxin (cardiac glycoside)
  • People taking thiazide diuretics (monitor calcium)
  • Those with vitamin D blood levels already over 60 ng/mL

  1. Take 1 softgel (3000 IU) daily with food containing fats
  2. Best absorbed with meals including oils, nuts, or fatty fish
  3. Swallow softgel whole with 8oz of water
  4. Can be taken any time of day for convenience
  5. Take consistently every day for stable blood levels
  6. Test vitamin D levels after 8-12 weeks initially
  7. Target blood level range of 40-60 ng/mL
  8. Combine with vitamin K2 and magnesium for synergy
  9. Adjust dose based on blood test results
  10. Store in cool, dry place away from heat and light

Results: Meta-analyses demonstrate vitamin D supplementation (800-4000 IU daily) reduces respiratory infections by 30-50%, with greatest benefit in deficient individuals achieving optimal blood levels.

Citation: Martineau AR, et al. "Vitamin D supplementation to prevent acute respiratory tract infections." BMJ. 2017;356:i6583.

Results: Studies show vitamin D improves insulin sensitivity by 15-30%, reduces diabetes risk by 25-40%, and lowers blood pressure by 5-8/3-5 mmHg in deficient populations.

Citation: Pittas AG, et al. "Vitamin D and cardiometabolic outcomes." Annals of Internal Medicine. 2010;152(5):307-314.

Results: Clinical trials demonstrate vitamin D supplementation increases calcium absorption by 30-60%, reduces fracture risk by 20-35%, and improves muscle strength by 10-25%.

Citation: Bischoff-Ferrari HA, et al. "Fracture prevention with vitamin D supplementation." JAMA. 2005;293(18):2257-2264.

Results: Research shows 3000 IU daily achieves optimal blood levels (40-60 ng/mL) in 70-85% of adults within 8-12 weeks, supporting comprehensive health benefits.

Citation: Heaney RP, et al. "Vitamin D distribution and status as a key determinant of health." Nutrition Research Reviews. 2011;24(2):206-216.