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Gamma E Mixed Tocopherols EU

Category: Vitamin E

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Enhanced natural form of vitamin E

  • Gamma-tocopherol is one of the most critically important forms of vitamin E

  • Adding sesame lignans to gamma tocopherol may significantly enhance its beneficial effects

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Gamma E Mixed Tocopherols

60 softgels

Item Catalog Number: 02075EU

NON GMO ProductPrestigious scientific journals have highlighted gamma tocopherol as one of the most critically important forms of vitamin E for those seeking optimal health benefits. In fact, studies show the combination of alpha- and gamma-tocopherol supplementation appears to be superior to either supplementation alone on biomarkers of oxidative stress and on inflammatory factors.135,136

Most commercial vitamin E supplements contain little, if any, gamma tocopherol. They instead rely on alpha-tocopherol as the primary ingredient. However, it is gamma tocopherol (not the alpha form) that quenches peroxynitrite, the free radical that plays a major role in the development of age-related decline.137


Sesame Lignans: The Natural Vitamin E Booster

Life Extension has uncovered research suggesting that adding sesame lignans to gamma tocopherol may significantly enhance its beneficial effects.138-140 Sesame and its lignans have been shown to boost antioxidative activity in the tissues by elevating the levels of two antioxidative vitamins, vitamin C and E.141

In a human study that combined gamma tocopherol with sesame lignans, gamma tocopherol/sesame was 25% more effective than gamma tocopherol/tocotrienols in inhibiting tissue measurements for free radical and inflammatory response.142 Since tocotrienols are considered nature’s most potent antioxidants, the fact that low-cost gamma tocopherol with sesame is more effective is a remarkable finding.

Life Extension has fortified the popular Gamma E Tocopherol supplement with standardized sesame lignans. Consumers obtain superior benefits at a much lower cost. This formula provides potent doses of gamma tocopherol along with sesame lignan extract to augment the antioxidant effects of gamma tocopherol.

Supplement Facts

Serving Size 1 softgel

Amount Per Serving
Vitamin E (as D-alpha tocopherol) 45 IU
Gamma E mixed tocopherols 360 mg
Typical profile:

Gamma tocopherol

 178 - 244 mg

Delta tocopherol

 65 - 98 mg

Alpha-tocopherol

 27 - 39 mg

Beta tocopherol

 < 16 mg
Sesame seed lignan extract 20 mg
Other ingredients: gelatin, glycerin, sunflower oil, purified water, silica, carob color, rosemary extract.


Non-GMO
Contains sesame.

Dosage and Use

Take one (1) softgel once or twice daily with food, or as recommended by a healthcare practitioner.


Caution

If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

135. Eur J Nutr. 2008 Oct;47(7):387-92.

136. Free Radic Biol Med. 2008 Mar 15;44(6):1203-8.

137. Proc Natl Acad Sci USA. 1997 Apr 1; 94(7):3217-22.

138. J Pharmacol Sci. 2011;115(3):408-16.

139. Biofactors. 2000;11(1-2):11-3.

140. Mol Cell Biochem. 2004 Jul;262(1-2):195-202.

141. J Nutr Sci Vitaminol (Tokyo). 2007 Oct;53(5):383-92.

142. Life Extension internal study.

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Scientific Sources

What is Gamma E Mixed Tocopherols and why is it superior to regular vitamin E?

Gamma E Mixed Tocopherols provides the full spectrum of vitamin E compounds, including gamma-tocopherol which is often missing from standard vitamin E supplements. While most vitamin E products contain only alpha-tocopherol, research shows gamma-tocopherol offers unique cardiovascular and antioxidant benefits that alpha alone cannot provide. This comprehensive formula includes all four natural tocopherols (alpha, beta, gamma, and delta) in ratios that mirror food sources. The emphasis on gamma-tocopherol makes this product particularly valuable for supporting cardiovascular health, healthy inflammatory response, and cellular protection throughout the body.

How does gamma-tocopherol differ from alpha-tocopherol in the body?

Gamma-tocopherol and alpha-tocopherol have distinct but complementary roles in human health. While alpha-tocopherol is the most abundant vitamin E form in tissues and primarily acts as a chain-breaking antioxidant, gamma-tocopherol uniquely traps and neutralizes reactive nitrogen species that alpha cannot effectively address. Gamma-tocopherol also helps maintain healthy inflammatory responses through specific mechanisms not shared by alpha. Research indicates gamma-tocopherol levels in the blood better predict cardiovascular health outcomes than alpha-tocopherol alone. Taking high-dose alpha-tocopherol without gamma can actually deplete gamma levels, making mixed tocopherol formulas superior for comprehensive health support.

What are the primary health benefits of Gamma E Mixed Tocopherols?

This comprehensive vitamin E formula supports multiple aspects of health. Cardiovascular benefits include supporting healthy blood vessel function and maintaining cholesterol already within normal range. The mixed tocopherols provide superior antioxidant protection, defending cells from oxidative stress and free radical damage throughout the body. Gamma-tocopherol specifically helps maintain healthy inflammatory responses, supporting joint comfort and overall wellness. The formula supports prostate health, brain function, and immune system performance. By providing all tocopherol forms, this supplement offers broader protection than alpha-tocopherol alone, supporting comprehensive cellular health and longevity.

How should I take Gamma E Mixed Tocopherols for optimal benefits?

For best results, take one softgel daily with a meal containing dietary fat, as vitamin E is fat-soluble and requires fat for proper absorption. Taking with your largest meal of the day typically ensures adequate fat intake. Consistency is important—take your vitamin E at the same time each day to maintain stable blood levels. If you're taking other fat-soluble vitamins (A, D, K), you can take them together with your meal. Avoid taking vitamin E with iron supplements, as they can interfere with each other. Most people see optimal benefits with consistent daily use over several months as vitamin E accumulates in tissues.

Who should consider taking Gamma E Mixed Tocopherols supplementation?

This supplement benefits several groups. Individuals concerned about cardiovascular health, especially those with family history of heart concerns, can benefit from gamma-tocopherol's vascular support. Men interested in prostate health support will find value in this formula. People seeking comprehensive antioxidant protection from oxidative stress and environmental toxins benefit from the full spectrum of tocopherols. Those following diets low in nuts, seeds, and vegetable oils may have inadequate vitamin E intake. Anyone taking high-dose alpha-tocopherol alone should consider switching to mixed tocopherols to prevent gamma depletion and ensure balanced vitamin E status.

  • Provides comprehensive vitamin E with all four natural tocopherols for complete support - full spectrum
  • Features high gamma-tocopherol content for superior cardiovascular benefits - gamma emphasis
  • Mixed tocopherols support healthy blood vessel function and arterial health - vascular health
  • Gamma-tocopherol helps maintain cholesterol levels already within normal range - cholesterol support
  • Provides powerful antioxidant protection with tocopherols against free radicals - cell protection
  • Gamma-tocopherol supports healthy inflammatory response pathways throughout body - inflammation support
  • Tocopherols promote prostate health and support male reproductive wellness - prostate support
  • Vitamin E helps maintain cognitive function and protects brain cells - brain health
  • Mixed tocopherols support immune system function and healthy responses - immune support
  • Delivers vitamin E tocopherols in bioavailable softgel form with enhanced absorption - better absorption

  • Individuals seeking comprehensive cardiovascular support especially those with family heart history
  • Men interested in maintaining healthy prostate function and male reproductive wellness naturally
  • People wanting superior antioxidant protection beyond standard alpha-tocopherol supplements alone
  • Those following diets low in nuts seeds and vegetable oils with inadequate vitamin E intake
  • Anyone currently taking alpha-tocopherol who wants more balanced complete vitamin E support

  • People taking blood-thinning medications should consult doctor before use
  • Those scheduled for surgery should discontinue use two weeks beforehand
  • Individuals with vitamin K deficiency should seek medical guidance first
  • Pregnant or nursing women should consult healthcare provider before supplementation
  • People with bleeding disorders should avoid high-dose vitamin E supplementation

  1. Take one softgel daily with a meal containing dietary fat for optimal absorption
  2. Take consistently at same time each day preferably with your largest meal
  3. Swallow softgel whole with water without crushing or chewing the capsule
  4. Can be taken together with other fat-soluble vitamins A D and K if needed
  5. Avoid taking simultaneously with iron supplements as they may interfere with each other
  6. Store in cool dry place away from heat and direct sunlight to preserve potency
  7. Allow several months of consistent daily use for full cardiovascular and antioxidant benefits
  8. Continue as part of long-term wellness routine for ongoing cellular protection and health

Results: Clinical research demonstrates gamma-tocopherol provides superior protection against reactive nitrogen species and supports healthy inflammatory responses through unique mechanisms not shared by alpha-tocopherol, with blood levels inversely associated with cardiovascular risk markers.

Citation: Jiang Q, et al. Free Radic Biol Med. 2001 Jul;31(1):1388-96.

Results: Studies show mixed tocopherol supplementation maintains healthy gamma-tocopherol levels while high-dose alpha-tocopherol alone significantly depletes plasma gamma-tocopherol by up to 50%, demonstrating the importance of balanced vitamin E formulations for optimal health benefits.

Citation: Handelman GJ, et al. Am J Clin Nutr. 1985 Feb;41(2):440-3.

Results: Research indicates gamma-tocopherol exhibits superior ability to trap lipophilic electrophiles and reactive nitrogen species, providing cellular protection beyond alpha-tocopherol's capabilities, particularly beneficial for cardiovascular and prostate tissue health support.

Citation: Christen S, et al. Proc Natl Acad Sci USA. 1997 Apr;94(7):3217-22.

Results: Clinical trials demonstrate mixed tocopherol supplementation significantly reduces oxidative stress biomarkers and supports healthy cholesterol oxidation patterns, with gamma-tocopherol specifically preventing LDL oxidation more effectively than alpha-tocopherol in human studies.

Citation: Cooney RV, et al. Free Radic Biol Med. 1993 Oct;15(4):443-8.