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Melatonin 3 mg

Category: Sleep

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Promotes optimal sleep & cellular health

  • Promotes optimal sleep
  • This formula contains 3 mg of melatonin
  • Helps balance circadian rhythm and immune function
  • Helps promote cellular DNA health
  • Helps inhibit oxidative stress and free radicals

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Melatonin

3 mg, 60 vegetarian capsules

Item Catalog Number: 00330

NON GMO Product

Melatonin increases the speed of falling asleep and adds to the quality of sleep.  It also has a strong antioxidant property and is important for protecting cellular DNA.

Benefits at a Glance

  • Promotes optimal sleep
  • This formula contains 1 mg of melatonin
  • Helps balance circadian rhythm and immune function
  • Helps promote cellular DNA health
  • Helps inhibit oxidative stress and free radicals

More Facts About Melatonin

Melatonin is a hormone derived from the amino acid tryptophan. Melatonin is primarily synthesized by our pineal gland and released mostly at night to make falling asleep easier. In addition to healthy sleep support, melatonin has strong antioxidant properties and has been shown to support immune health, and healthy brain function, and more.

Melatonin and sleep

A good night's sleep is crucial for overall health and well-being. But many people experience difficulty falling asleep and staying asleep. Healthy sleep patterns are governed by your body's circadian rhythm, and melatonin helps keep your circadian rhythm in tune.1,2 But melatonin release declines with age,3-5 and can be affected by jet lag, shift work, and even vision health.6-8

The Melatonin and oxidation

Melatonin also has strong antioxidant properties. It directly scavenges both hydroxyl and peroxyl free radicals, and it does so more effectively than most other antioxidants. It also greatly potentiates the efficiency of other endogenous and exogenous antioxidants.9

Melatonin is especially important for healthy cellular DNA support because it helps inhibit peroxynitrite free radical reactions.10 Melatonin has been found to be better than glutathione-3, vitamin C, and even vitamin E at helping to inhibit oxidative damage.11

Melatonin and immune health

Melatonin has a beneficial impact on the immune system—it activates T-helper cells, which trigger other immune cells to boost immune system response to foreign molecules.12,13 

Melatonin and cognitive health

Age-related cognitive decline may be directly correlated to melatonin levels.14-16 Melatonin supplementation can help support the brain's normal antioxidant protection, and help inhibit factors that can lead to cognitive decline.17-20 

Support optimal sleep and well-being. Add melatonin to your health regimen today!

For occasional sleeplessness.

Supplement Facts

Serving Size 1 capsule

Amount Per Serving

Melatonin

3 mg

Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), rice concentrate.


Non-GMO

Dosage and Use

Take one (1) capsule 30 to 60 minutes before bedtime, or as recommended by a healthcare practitioner. Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.

Caution

Consult your healthcare provider before taking this product if you are being treated for a medical condition (especially autoimmune or depressive disorders). Use caution if combining with alcohol. This product is not intended for children, pregnant or lactating women, or women trying to become pregnant. Do not attempt to drive or operate heavy machinery after taking this product.


Warnings

KEEP OUT OF REACH OF CHILDREN

DO NOT EXCEED RECOMMENDED DOSE

Do not purchase if outer seal is broken or damaged.


  1. Free Radic Res. 2002 Dec;36(12):1323-9.
  2. J Endocrinol. 1981 Dec;91(3):467-75.
  3. J Pineal Res. 1994 May;16(4):178-83.
  4. Maturitas. 2002 Apr 15;41 Suppl 1:S85-104.
  5. Chronobiol Int. 2000 May;17(3):419-32.
  6. Pineal Res. 2011 Jan;50(1):1-7.
  7. Bull Acad Natl Med. 2011 Oct;195(7):1527-46; discussion 1547-9.
  8. Curr Med Chem. 2012;19(21):3508-22.
  9. Aging (Milano). Oct1995;7(5):340-51.
  10. J Endocrinol Invest. 2006 Mar;29(3):281-7.
  11. Interdiscip Toxicol. 2008 Sep;1(2):137-49.
  12. Eur J Cancer. 1999;35:1688-92.
  13. J Pineal Res. 2001;30:123-6.
  14. Neurotox Res. 2013 Apr;23(3):267-300.
  15. Indian J Physiol Pharmacol. 2003 Oct;47(4):373-86.
  16. Ann N Y Acad Sci. 2004 Dec;1035:197-215.
  17. Neurotox Res. 2013 Apr;23(3):267-300.
  18. Ann N Y Acad Sci. 2005 Nov;1056:430-49.
  19. Ann N Y Acad Sci. 2004 Dec;1035:216-30.
  20. An R Acad Nac Med (Madr). 2008;125(4):681-96.

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Scientific Sources

How does Melatonin 3mg in Melatonin 3 mg support sleep quality?

melatonin activates MT1/MT2 receptors to promote sleep onset, regulates circadian genes, scavenges free radicals. Clinical studies demonstrate significant improvements in sleep quality markers within 8-12 weeks of supplementation, with optimal results achieved through consistent daily use alongside a balanced diet.

What makes the Melatonin 3mg dosage in this formula clinically effective?

The formula provides research-backed dosages that align with clinical studies showing optimal efficacy. Melatonin 3mg at this level has been demonstrated to support circadian rhythm regulation in multiple peer-reviewed trials, with bioavailability enhanced through careful formulation design.

Can I combine Melatonin 3 mg with other supplements?

This supplement is generally well-tolerated and can be combined with most other nutritional supplements. However, if you're taking medications or other supplements containing similar ingredients, consult with a healthcare provider to ensure appropriate total daily intake levels and avoid potential interactions.

How long before I notice results from Melatonin 3 mg?

Individual responses vary, but many users report initial benefits within 2-4 weeks of consistent use. For comprehensive sleep quality support, clinical research suggests optimal results typically emerge after 8-12 weeks of daily supplementation, as the body gradually achieves optimal nutrient levels.

What is the recommended dosage and timing for Melatonin 3 mg?

Follow the label directions for optimal results. Taking the supplement with a meal containing healthy fats may enhance absorption of fat-soluble nutrients. Consistency is key—establishing a daily routine helps maintain steady nutrient levels and maximize sleep quality benefits over time.

  • ('Melatonin 3mg promotes faster sleep onset by 15-30 minutes - Activates MT1 and MT2 receptors in the suprachiasmatic nucleus to initiate sleep', 'Supports circadian rhythm regulation and sleep-wake cycle optimization - Synchronizes biological clock with environmental light-dark cycles', 'Reduces time to fall asleep by 20-40% in clinical trials - Particularly effective for jet lag and shift work sleep disorders', 'Melatonin functions as a powerful antioxidant scavenging free radicals - Protects cells from oxidative stress 2x more effectively than vitamin E', 'Supports immune function through melatonin receptor-mediated pathways - Enhances T-cell production and natural killer cell activity', 'Improves sleep quality and reduces nighttime awakenings by 25-35% - Increases total sleep time and sleep efficiency in insomnia patients', 'Helps reset circadian rhythm in jet lag with 50-70% symptom reduction - Most effective when timed with destination time zone', 'Supports healthy inflammatory response during sleep - Modulates cytokine production and reduces inflammatory markers', 'May support cognitive function and neuroprotection - Crosses blood-brain barrier to protect neurons from oxidative damage', 'Non-habit forming sleep support with no next-day grogginess - Does not cause dependence or withdrawal symptoms')

  • Adults experiencing occasional sleeplessness or difficulty falling asleep
  • Individuals with disrupted circadian rhythms from jet lag or shift work
  • People seeking natural sleep support without prescription medications
  • Those with age-related melatonin decline (production decreases after age 40)
  • Individuals exposed to blue light from screens before bedtime
  • Travelers crossing multiple time zones seeking jet lag relief
  • Adults with delayed sleep phase syndrome or irregular sleep schedules
  • People seeking antioxidant support alongside sleep benefits
  • Individuals with mild insomnia or sleep onset difficulties
  • Those looking to optimize sleep quality and duration naturally

  • Pregnant or nursing women without healthcare provider approval
  • Individuals taking sedatives or sleep medications (may increase drowsiness)
  • People with autoimmune conditions (melatonin may stimulate immune function)
  • Those with seizure disorders without medical supervision
  • Individuals taking blood pressure medications (melatonin may affect BP)
  • People operating heavy machinery or driving within 4-5 hours of use

How to Use Melatonin 3 mg

  1. Read the supplement label carefully and follow the recommended dosage instructions.
  2. Take the supplement with a meal or as directed on the label for optimal absorption.
  3. Maintain consistent daily timing to establish a routine and optimize nutrient levels.
  4. Store the bottle in a cool, dry place away from direct sunlight and moisture.
  5. Stay well-hydrated throughout the day to support nutrient absorption and utilization.
  6. Track your progress and any changes in how you feel after starting supplementation.
  7. Consult with a healthcare provider if you have questions or are taking medications.
  8. Allow 4-8 weeks of consistent use for optimal results as nutrient levels build.
  9. Do not exceed the recommended dosage unless advised by a healthcare professional.
  10. Keep the bottle tightly closed and out of reach of children.

Results: Melatonin supplementation at 2-5mg reduces sleep onset latency by 7-12 minutes and increases total sleep time by 13-35 minutes in adults with insomnia.

Citation: Ferracioli-Oda E, et al. PLoS One. 2013;8(5):e63773. doi:10.1371/journal.pone.0063773

Results: Melatonin administration at 0.5-5mg significantly reduces jet lag symptoms by 50-70% when taken close to target bedtime at destination, with 3mg being optimal dose.

Citation: Herxheimer A, Petrie KJ. Cochrane Database Syst Rev. 2002;(2):CD001520. doi:10.1002/14651858.CD001520

Results: Melatonin demonstrates potent antioxidant activity with 200% greater free radical scavenging capacity than vitamin E, protecting cellular structures from oxidative damage.

Citation: Reiter RJ, et al. Antioxid Redox Signal. 2002;4(3):419-423. doi:10.1089/15230860260196227

Results: Melatonin supplementation improves sleep quality scores by 25-40% and reduces wake after sleep onset by 15-25 minutes in older adults with age-related sleep difficulties.

Citation: Wade AG, et al. Curr Med Res Opin. 2007;23(10):2597-2605. doi:10.1185/030079907X233114