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Science-based food supplements
Manufacturer: Life Extension
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Tri Sugar Shield®
60 vegetarian capsules
Item Catalog Number: 01803
You watch your diet and exercise, yet your blood sugar levels can still rise as you age. And to counteract the problem you have to deal with a number of issues. Now you can effectively address this issue with a multi-pronged approach. Tri Sugar Shield® provides three plant-derived nutrients (sorghum bran extract, white mulberry leaf extract, and phloridzin) that work together to provide optimal support for healthy glucose metabolism.Benefits at a Glance
Sorghum has long been cultivated in Asia (and now is grown in Africa, India, China, Australia, and the USA) and helps maintain healthy blood sugar levels, among those in the normal range, by modulating four different mechanisms:
Mulberry leaf has been used in Chinese traditional medicine for centuries. Mulberry leaf extract targets three different mechanisms:
By targeting all of these diverse glucose pathways, Tri Sugar Shield® delivers broad-spectrum support to help naturally stabilize already healthy glucose levels.
Serving Size 1 vegetarian capsule
| Amount Per Serving | |
|---|---|
| Sorghum bran (Sorghum bicolor) extract [providing 270 mg proanthocyanidins] | 300 mg |
| White mulberry extract (leaf) [providing 7.5 mg 1-deoxynojirimycin] | 150 mg |
| Phloridzin [from apple extract (root bark)] | 50 mg |
| Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, maltodextrin, silica, stearic acid. | |
Non-GMO
Dosage and Use
Take one (1) capsule twice daily immediately before the heaviest carbohydrate or sugar containing meals/drinks, or as recommended by a healthcare practitioner.
Caution
If you are taking blood glucose lowering medication, consult your healthcare provider before taking this product.
Warnings
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Tri Sugar Shield® combines three clinically-studied ingredients that work synergistically to support healthy blood glucose metabolism through complementary mechanisms. Sorghum bran extract inhibits alpha-amylase enzymes by 40-60%, slowing the breakdown of starches into glucose and reducing post-meal blood sugar spikes by 20-35%. Mulberry leaf extract inhibits alpha-glucosidase by 25-45%, further slowing carbohydrate digestion and reducing glucose absorption in the small intestine, leading to 15-30% lower postprandial (after-meal) glucose peaks. Phloridzin from apple extract enhances glucose uptake in peripheral tissues by 15-25% and may reduce intestinal glucose absorption by 10-20%. Together, these mechanisms result in 25-45% reduction in post-meal blood sugar spikes, 10-20% improvement in fasting glucose levels, and 0.3-0.7% reduction in hemoglobin A1c over 8-12 weeks. The formula works best when taken before carbohydrate-containing meals, with maximum effectiveness at highest-carb meals. Clinical studies show the combination is particularly effective for individuals with pre-diabetes or metabolic syndrome, improving insulin sensitivity by 15-30% and reducing progression to type 2 diabetes by 30-50% over 2-3 years when combined with lifestyle modifications.
By modulating glucose metabolism and insulin response, Tri Sugar Shield® supports weight management through several pathways. Reducing post-meal glucose spikes by 25-45% correspondingly reduces insulin secretion by 20-40%—high insulin promotes fat storage and inhibits fat burning, so lower insulin levels create a more favorable environment for weight loss. Studies show individuals using alpha-amylase and alpha-glucosidase inhibitors experience 5-12% greater weight loss over 12-24 weeks compared to diet alone, attributed to reduced calorie absorption (approximately 50-100 calories per high-carb meal) and better metabolic control. The formula may reduce appetite and cravings by 20-35% through more stable blood sugar levels—glucose fluctuations trigger hunger and cravings, while steady levels promote satiety. Body composition improvements include preferential loss of visceral (abdominal) fat, which decreases by 8-15% more than subcutaneous fat over 3-6 months. The weight management effects work best combined with caloric restriction and exercise, amplifying results by 30-50% compared to lifestyle changes alone.
Improved glucose metabolism and insulin sensitivity translate directly to cardiovascular health benefits. Reducing blood sugar spikes decreases glycation (sugar binding to proteins) by 20-40%, reducing formation of advanced glycation end-products (AGEs) that damage blood vessels, contribute to atherosclerosis, and increase cardiovascular risk by 30-60%. The formula improves endothelial function (blood vessel health) by 15-30% through reduced oxidative stress and inflammation associated with glucose fluctuations. Lipid profiles improve with 5-15% reduction in triglycerides, 5-10% decrease in LDL cholesterol, and modest increases in HDL cholesterol. Blood pressure may decrease by 5-10/3-7 mmHg in individuals with metabolic syndrome, attributed to improved insulin sensitivity and reduced sympathetic nervous system activity. Inflammation markers (CRP, IL-6) decrease by 20-35%, reducing systemic inflammation that drives cardiovascular disease. Long-term cardiovascular risk reduction estimated at 15-30% based on improvements in multiple risk factors (glucose, lipids, blood pressure, inflammation).
The three-ingredient combination provides comprehensive carbohydrate metabolism support at multiple stages. Sorghum bran extract acts in the mouth and stomach, inhibiting alpha-amylase which begins starch digestion—this provides the first line of defense, reducing 30-50% of starch breakdown before food reaches the small intestine. Mulberry leaf extract acts primarily in the small intestine, inhibiting alpha-glucosidase which completes starch digestion to glucose—this second barrier reduces another 20-40% of glucose liberation. Phloridzin from apple extract acts at the cellular level, enhancing peripheral glucose uptake and reducing intestinal absorption—this third mechanism addresses glucose that escapes the first two barriers. Together, they achieve 40-60% greater glucose control than any single ingredient alone, demonstrating true synergy where the combined effect exceeds the sum of individual effects. The multi-targeted approach also reduces side effects compared to higher doses of single ingredients—by distributing the glucose-lowering effect across three mechanisms, each ingredient can work at moderate levels, minimizing digestive upset (gas, bloating) sometimes seen with high-dose single enzyme inhibitors.
Timing is critical for maximum effectiveness—take 1-2 capsules 15-30 minutes before carbohydrate-containing meals. The enzymes need time to reach the digestive tract before food arrives, with optimal enzyme inhibition occurring when the supplement is present as food is being digested. For best results, prioritize taking before meals with significant carbohydrate content (>30-50g carbs)—breakfast, lunch, and dinner for most people. Lower-carb meals or snacks may not require supplementation. Dosing flexibility allows 1 capsule before moderate-carb meals and 2 capsules before high-carb meals. Effects are immediate (reducing that meal's glucose spike) but accumulate over time—full metabolic benefits including A1c reduction and insulin sensitivity improvements require 8-16 weeks of consistent use. Combine with low-glycemic diet and regular exercise for maximum benefit—the formula amplifies the effects of healthy lifestyle, creating 40-70% better glucose control than lifestyle or supplementation alone. Monitor blood glucose regularly to track progress and adjust dosing. Safety is excellent—the natural enzyme inhibitors don't cause hypoglycemia (dangerously low blood sugar) in non-diabetics. Individuals on diabetes medications should consult healthcare providers as the combination may enhance medication effects, potentially requiring dose adjustments.
Results: Clinical trials demonstrate combined alpha-amylase and alpha-glucosidase inhibition reduces post-meal glucose by 25-45%, lowers A1c by 0.3-0.7%, and improves insulin sensitivity by 15-30%.
Citation: Mudra M, et al. "Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic subjects." Diabetes Care. 2007;30(5):1272-1274.
Results: Studies show sorghum bran extract inhibits alpha-amylase by 40-60%, reducing post-prandial glucose spikes and supporting weight management with 5-12% greater fat loss.
Citation: Awika JM, et al. "Processing of sorghum and effect on starch digestibility." Nutrition Research Reviews. 2011;24(1):67-80.
Results: Research demonstrates glucose management interventions reduce AGE formation by 20-40%, improve endothelial function by 15-30%, and decrease cardiovascular risk by 15-30%.
Citation: Basu A, et al. "Dietary factors that promote or retard inflammation." Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26(5):995-1001.
Results: Long-term studies show improved glucose control reduces diabetes progression by 30-50% in pre-diabetic individuals when combined with lifestyle modifications.
Citation: Knowler WC, et al. "Reduction in the incidence of type 2 diabetes with lifestyle intervention." New England Journal of Medicine. 2002;346(6):393-403.