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Probiotics supports mood and relaxation

11588 Views Posted on: 2019-09-18
Posted by: Ireneusz Adamczyk
Probiotics supports mood and relaxation

Anxiety and mood disorders are now being recognized as major medical and societal issues. With millions of people medicated for mood disorders that include anxiety and mild depression, researchers have sought a safer way to reduce their impact.

In a unique discovery, two specific probiotic organisms have been identified that show impressive reductions in the manifestation of stress, anxiety, and depression.

Human studies on two unique probiotics (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) show notable results. For example, one study showed a 50% decrease in depression scores while another showed a 55% improvement in anxiety scores.5,6

While it may seem remarkable that a probiotic can have effects outside of the gastrointestinal tract, a massive accumulation of data suggests that the gut is, in fact, practically a “second brain,” with a powerful and lasting impact on mood.

“Gut-Brain Axis”

Depression and anxiety are highly prevalent in the US (and around the world), affecting approximately 6.7% and 18.1% of Americans respectively.8,9
Gut-Brain AxisUntil quite recently, these mental health disorders were viewed as primarily related to brain function, since it has long been believed that the brain is solely responsible for thoughts, feelings, and behavior.
There is an increasing awareness among scientists of the role played by the microorganisms that live in the gastrointestinal tract in affecting other body systems, including the brain.10

In fact, the close relationship between the microbes in the gastrointestinal tract and the biochemical functioning of brain cells and structures has given rise to the term gut-brain axis, indicating that what happens in the gut can affect the brain, and vice versa.12,13

Animal studies show that the makeup of organisms in the gastrointestinal tract (intestinal flora) can affect brain development in young animals, influencing specific behaviors such as anxiety.14,15 Conversely, early life stresses can change the makeup of the gastrointestinal flora, accompanied by increases in stress hormones such as cortisol, in immune system responses, and in intestinal pain sensations.16

Therefore, deliberately introducing changes to the gastrointestinal flora through supplementation with probiotics is an exciting new way to introduce changes in how the brain functions, including how people experience emotions.10,17-19

Mechanisms of Probiotic Impact on Stress

Mechanisms of Probiotic Impact on Stress

High-quality, reliable animal models of stress, anxiety, and depression have been developed in the pursuit of chemical drugs to treat these conditions.28-31

In addition, various biochemical markers have been identified that can help indicate an animal’s state of stress and its responses, which are useful in determining the effects of an intervention such as a drug or a supplement.

These markers include hormones such as cortisol and the closely related corticosterone, both of which correlate with chronic stress, as well as epinephrine (adrenaline) and norepinephrine (noradrenaline), which indicate immediate stress and anxiety.

Such animal models have now been used to study the impact of the probiotic combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175.

Reducing Anxiety, Depression, and Stress Safely

  • Gut-Brain AxisStress, anxiety, and depression affect millions of Americans.
  • Mainstream medicine relies on costly medications, with only partial effectiveness and substantial side effects, in an attempt to manage these conditions.
  • The recognition of the enormous role played by the intestinal flora, the community of microorganisms living in our intestines, has shifted attention to these organisms as potential partners in managing human mental illnesses.
  • Changing the composition of the intestinal flora has been shown in animal studies to significantly affect behaviors and biochemical markers of stress, anxiety, and depression.
  • The combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 was specifically developed with mental health in mind.
  • This probiotic combination, in oral form, has been proven in human and animal studies to relieve symptoms of anxiety and depression, while demonstrating reductions in stress and anxiety-promoting hormones.
  • For anyone currently using medication to manage symptoms of depression and/or anxiety, the new probiotic combination deserves a hard look, both for its effectiveness and for its safety.

Human Studies Show Dramatic Reductions in Anxiety and Depression

Even high-quality animal models are limited in what they can tell us about any drug or supplement’s impact on human mood and behaviors. That’s why human randomized, placebo-controlled trials are so important. Such studies have now been carried out using the probiotic Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 combination.

A human study of 55 participants with mild depression or anxiety, ages 30 to 60, was conducted to determine the effects of the probiotic combination on anxiety, depression, stress, and coping strategies.5 Subjects were given 3 billion colony-forming-units (CFUs, a measure of the number of individual organisms) of the probiotic, or a placebo, for 30 days.

The probiotic-supplemented subjects had a significantly larger drop in measures of anxiety and depression than did placebo recipients as follows:
  • Human Studies Show Dramatic Reductions in Anxiety and Depression49% drop in the global severity index, a measure of overall psychological distress
  • 50% decrease in depression scores
  • 60% decrease in anger-hostility scores
  • 36% decrease in the hospital anxiety and depression score (HADS)
  • 13% decrease in urinary free cortisol, a hormonal measure of chronic stress, which was not seen in placebo patients.

Supplemented patients also displayed reductions in self-blame and higher problem-solving skills after the study.5

Even people who don’t consider themselves “high-stress” may attain a serenity boost from this novel probiotic combination. When the same research team analyzed data on 25 original study participants whose baseline cortisol was below the median, indicating generally lower stress, they found that these individuals also experienced marked improvements in mood scores.6

Another human study evaluated the impact of the probiotic combination on stress-induced digestive symptoms, a common manifestation of stress even in basically healthy people. Subjects ages 18 to 60, with at least two self-reported symptoms of stress (nervousness, irritability, anxiety, sleeping problems, gastrointestinal disturbances), were randomly assigned to receive either placebo or the probiotic combination at the same dosage as in the other studies.

Compared with placebo, supplemented subjects had a significant 7.6-fold greater reduction in stress-induced abdominal pain, and a significant 2.1-fold greater reduction in stress-induced nausea and vomiting. For many of us, these effects alone would make the supplement worthwhile!36

Summary

Depression and anxiety are serious medical conditions that can be disabling, and in the case of depression and suicide, fatal.

Supplementation with the probiotic combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 is an evidence-based, biologically plausible approach to addressing symptoms of depression, anxiety, and stress.

Studies show favorable biochemical and behavioral changes in animals treated with the probiotic, and sharp and significant decreases in symptoms of depression and anxiety in human trials.

For anyone experiencing anxiety and/or depression, regular supplementation with this probiotic combination seems a natural and worthwhile practice. It is conceivable that such supplementation could reduce reliance on prescription medications and deliver freedom from the burdens of these common mental illnesses.

Material used with permission of Life Extension. All rights reserved.

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Scientific Sources

50% depression score decrease?

Human studies on two unique probiotics (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) show notable results. One study showed 50% decrease in depression scores while another showed 55% improvement in anxiety scores. Demonstrates powerful mood-regulating effects of specific probiotic strains.

55% anxiety improvement?

Another study showed 55% improvement in anxiety scores with same probiotic combination. L. helveticus R0052 and B. longum R0175 demonstrate targeted effects on anxiety symptoms through gut-brain axis modulation.

6.7% and 18.1% prevalence?

Depression and anxiety highly prevalent in US (and around world), affecting approximately 6.7% and 18.1% of Americans respectively. Until quite recently, these mental health disorders viewed as primarily related to brain function. Gut-brain axis now recognized as critical.

13% cortisol decrease?

Study showed 13% decrease in urinary free cortisol, hormonal measure of chronic stress, which was not seen in placebo patients. Demonstrates objective biological stress reduction beyond subjective symptom improvement.

Gut-brain axis mechanism?

Mental health disorders now recognized as involving gut-brain axis. Specific probiotic strains L. helveticus R0052 and B. longum R0175 modulate this bidirectional communication pathway between gastrointestinal tract and central nervous system, producing measurable mood and stress improvements.

  • 50% decrease depression scores L. helveticus R0052 + B. longum R0175
  • 55% improvement anxiety scores same probiotic combination
  • Two unique probiotic strains human studies notable results
  • 6.7% Americans depression highly prevalent condition
  • 18.1% Americans anxiety widespread mental health issue
  • 13% urinary cortisol decrease chronic stress hormone reduction
  • Not seen in placebo objective biological marker
  • Gut-brain axis modulation bidirectional communication
  • Beyond brain-only view paradigm shift mental health
  • Specific strain identification not all probiotics equal
  • Mood regulation documented clinical studies
  • Relaxation support stress response improvement
  • Objective and subjective benefits both measured
  • Gastrointestinal-CNS pathway mechanistic understanding

Probiotic Mood and Relaxation Protocol

Step 1: Understand Prevalence

Depression and anxiety are highly prevalent in US (and around world), affecting approximately 6.7% and 18.1% of Americans respectively. Until quite recently, these mental health disorders viewed as primarily related to brain function. Now recognized as involving gut-brain axis - bidirectional communication between gastrointestinal tract and central nervous system.

Step 2: 50% Depression Score Reduction

Human studies on two unique probiotics (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) show notable results. For example, one study showed 50% decrease in depression scores. Demonstrates powerful mood-regulating effects of these specific probiotic strains through gut-brain axis modulation.

Step 3: 55% Anxiety Improvement

Another study showed 55% improvement in anxiety scores with same probiotic combination. L. helveticus R0052 and B. longum R0175 demonstrate targeted effects on anxiety symptoms. Not all probiotics equal - strain specificity critical for mental health benefits.

Step 4: 13% Cortisol Reduction

Study showed 13% decrease in urinary free cortisol, hormonal measure of chronic stress, which was not seen in placebo patients. Demonstrates objective biological stress reduction beyond subjective symptom improvement. Cortisol marker validates real physiological changes, not just placebo effect.

Step 5: Specific Strain Selection

Critical to use exact strains validated in studies: Lactobacillus helveticus R0052 and Bifidobacterium longum R0175. Different strains have different effects. These specific strains shown to modulate gut-brain axis communication pathway producing measurable mood, anxiety, and stress improvements.

Step 6: Comprehensive Gut-Brain Support

Beyond probiotic supplementation, support gut-brain axis through: adequate sleep, stress management, regular physical activity, avoiding excessive antibiotics when possible, consuming prebiotic fiber to support probiotic colonization. Combined approach maximizes 50% depression and 55% anxiety improvements seen in studies.

  • Depression (F32.9 - 50% score decrease, 6.7% prevalence)
  • Anxiety disorders (F41.9 - 55% improvement, 18.1% prevalence)
  • Chronic stress (13% cortisol reduction)
  • Elevated cortisol hormonal stress marker
  • Mood disorders (F39)
  • Mental health conditions gut-brain axis involvement
  • Part of 6.7% depression prevalence
  • Part of 18.1% anxiety prevalence
  • Stress-related symptoms
  • Seeking mood regulation support
  • Gut-brain axis dysfunction
  • Immunocompromised severe without monitoring
  • Probiotic hypersensitivity
  • Short bowel syndrome

50% Depression Score Decrease with Specific Probiotic Strains: Human studies on two unique probiotics (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) show notable results. For example, one study showed 50% decrease in depression scores. Demonstrates powerful mood-regulating effects of these specific probiotic strains through gut-brain axis modulation, not achievable with generic probiotics.

Citation: Clinical trial using L. helveticus R0052 and B. longum R0175 combination documenting 50% reduction in depression scores on validated psychological assessment scales compared to baseline or placebo.

55% Anxiety Score Improvement: While another showed 55% improvement in anxiety scores using same probiotic combination. L. helveticus R0052 and B. longum R0175 demonstrate targeted effects on anxiety symptoms through gut-brain axis pathway modulation. Strain-specific effects validate precision probiotic approach to mental health.

Citation: Randomized controlled trial with L. helveticus R0052 and B. longum R0175 showing 55% improvement in anxiety scores on standardized anxiety assessment instruments.

6.7% and 18.1% Prevalence - Widespread Mental Health Impact: Depression and anxiety are highly prevalent in US (and around world), affecting approximately 6.7% and 18.1% of Americans respectively. Until quite recently, these mental health disorders were viewed as primarily related to brain function. Gut-brain axis now recognized as critical bidirectional communication pathway offering new therapeutic targets.

13% Urinary Cortisol Decrease - Objective Stress Marker: Study showed 13% decrease in urinary free cortisol, hormonal measure of chronic stress, which was not seen in placebo patients. Demonstrates objective biological stress reduction beyond subjective symptom improvement. Cortisol is gold standard stress hormone marker, validating real physiological changes not attributable to placebo effect.

Citation: Clinical study measuring urinary free cortisol levels showing 13% reduction in probiotic group (L. helveticus R0052 + B. longum R0175) versus no change in placebo group, establishing objective stress hormone modulation.