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Science-based food supplements
Manufacturer: Life Extension
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FLORASSIST® Prebiotic Chewable (Strawberry)
60 vegetarian chewable tablets
Item Catalog Number: 02203
Each strawberry-flavored tablet of FLORASSIST® Prebiotic Chewable contains a scientifically validated dose of PreticX™ prebiotic, which contains 70% xylooligosaccharides to optimize growth potential of beneficial bifidobacteria. Bifidobacteria occur naturally in the human gastrointestinal tract.
Benefits at a Glance:
These tiny organisms pack a powerful punch for better health. They benefit not only our digestive tracts but our whole body. And they produce specialized compounds associated with healthy metabolism and even longevity.1
Bifidobacteria metabolize important types of dietary carbohydrates. They also provide essential fuel to cells of the digestive tract and more.2,3 But bifidobacteria decrease in number as we age.4
One popular way to support bifidobacteria is to supplement with probiotics. But it is also important to make sure that these probiotics have an adequate prebiotic food source.
“Overdoing” prebiotics can be too much of a good thing. Most commercial prebiotics require large doses to provide the optimal conditions for GI colonization. Unfortunately, this can lead to unpleasant bloating, flatulence and general GI discomfort.2
FLORASSIST® Prebiotic Chewable is formulated with a scientifically validated, smaller dose of PreticX™ prebiotic, which contains 70% xylooligosaccharides. These xylooligosaccharides are ideal prebiotics because they are capable of optimizing the growth potential of gut bifidobacteria, and can do so in relatively low doses.3,4
The less actual prebiotic material you have to take, the less chance of gastrointestinal upset. This highly purified prebiotic is derived from non-GMO corn cob.
Serving Size 1 chewable tablet
| Amount Per Serving | |
|---|---|
| Total carbohydrate | 2 g |
|
PreticX™ Prebiotic |
1,400 mg |
| Other ingredients: xylitol, maltodextrin, mannitol, microcrystalline cellulose, natural beet color, natural strawberry flavor, glucose, D-xylose, stearic acid, croscarmellose sodium, arabinose, gum arabic, silica, stevia extract. | |
PreticX™ is a trademark of AIDP, Inc.
Dosage and Use
WARNINGS
KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
While probiotics are live beneficial bacteria that you consume directly, prebiotics are specialized plant fibers that serve as food for the beneficial bacteria already living in your gut. Think of probiotics as planting seeds in a garden, while prebiotics are the fertilizer that helps those seeds - and the plants already growing - thrive and multiply. Both play important roles in digestive health, but they work through different mechanisms.
FLORASSIST® Prebiotic Chewable contains PreticX™, a premium prebiotic ingredient providing 1,000mg of xylooligosaccharides (XOS) per serving. XOS are short-chain carbohydrates derived from plant sources that resist digestion in your stomach and small intestine, arriving intact in your colon where beneficial bacteria ferment them. This fermentation process produces beneficial compounds including short-chain fatty acids that support gut health in multiple ways.
What makes XOS particularly valuable is their selective fermentation by beneficial bacteria, especially Bifidobacteria. Unlike some fiber sources that can feed both beneficial and potentially harmful gut bacteria indiscriminately, XOS preferentially promote the growth of Bifidobacteria and other beneficial species while having minimal effect on less desirable bacteria. This selectivity makes prebiotics like XOS highly effective at shifting gut microbiome composition toward a healthier balance.
The chewable strawberry-flavored tablet format makes getting your daily prebiotic convenient and enjoyable. Many people find it difficult to consume adequate prebiotic fiber from diet alone - you'd need to eat large quantities of foods like onions, garlic, asparagus, and unripe bananas daily. This supplement provides a concentrated, clinically-studied dose of prebiotics in a form that's easy to take consistently.
Bifidobacteria deserve special mention as they're among the most important beneficial bacteria in your gut. These bacteria help break down complex carbohydrates, produce B vitamins and vitamin K, support immune function, help maintain the gut barrier that prevents harmful substances from entering your bloodstream, and produce beneficial metabolites that support overall health. By selectively feeding Bifidobacteria, FLORASSIST® helps maintain a gut environment that promotes optimal digestive function and overall wellness.
Xylooligosaccharides work through multiple complementary mechanisms to support both digestive function and immune system health. When you consume XOS, they pass through your stomach and small intestine largely undigested, reaching your colon intact. There, Bifidobacteria and other beneficial bacteria ferment the XOS, using them as fuel for growth and metabolic activities that produce beneficial byproducts.
One of the most important products of XOS fermentation is short-chain fatty acids (SCFAs), particularly butyrate, propionate, and acetate. Butyrate is especially valuable as it's the preferred energy source for the cells lining your colon (colonocytes). These cells require substantial energy to maintain the tight junctions between them that form your gut barrier. When colonocytes are well-nourished with butyrate, they maintain a robust barrier that prevents harmful substances, bacteria, and partially digested food particles from crossing into your bloodstream - a condition known as "leaky gut" when barrier function is compromised.
The immune system connection is profound and multifaceted. Approximately 70% of your immune system resides in or around your gut, where immune cells constantly monitor the trillions of bacteria and food particles passing through. A healthy, balanced gut microbiome dominated by beneficial bacteria like Bifidobacteria helps educate and regulate immune responses, preventing both inadequate responses to genuine threats and excessive responses to harmless substances (which can manifest as allergies or autoimmune reactions).
Research has shown that XOS supplementation can increase Bifidobacteria populations by 10-fold or more within just 2-3 weeks. This rapid shift toward beneficial bacteria creates a more favorable gut environment. The beneficial bacteria produce antimicrobial compounds that inhibit pathogenic bacteria, compete for nutrients and attachment sites on the gut wall (crowding out potentially harmful microbes), and produce vitamins and other beneficial metabolites.
XOS also supports regular bowel movements and comfortable digestion. The fermentation process produces gases and draws water into the colon, which helps maintain stool consistency and promote regularity without the harsh effects of stimulant laxatives. The gentle, natural support for digestive motility makes XOS-based prebiotics particularly valuable for people experiencing occasional constipation or irregular bowel patterns.
PreticX™ xylooligosaccharides have been studied in multiple clinical trials examining effects on gut microbiome composition, digestive function, and immune markers. One particularly well-designed study found that just 1 gram daily of XOS (the amount in one FLORASSIST® tablet) significantly increased Bifidobacteria populations within 2 weeks. By 8 weeks, Bifidobacteria levels had increased by over 10-fold compared to baseline, demonstrating the potent prebiotic effect.
Research comparing XOS to other prebiotic fibers has shown advantages in terms of effective dose and tolerance. While fructooligosaccharides (FOS) and galactooligosaccharides (GOS) - other common prebiotics - typically require 5-10 grams daily to produce significant effects, XOS shows beneficial effects at just 1-3 grams daily. This lower effective dose means less potential for the gas and bloating that can occur with higher doses of fermentable fibers.
A study examining XOS effects on immune function found that 8 weeks of supplementation increased secretory IgA levels in the gut by 25%. Secretory IgA is an important antibody that helps protect gut mucosa from pathogens and toxins. The increase suggests enhanced immune surveillance and protection at the gut barrier, which is your body's first line of defense against ingested threats.
Clinical research has also examined XOS effects on digestive comfort and regularity. Studies consistently show improvements in stool frequency and consistency, with participants reporting easier, more comfortable bowel movements. Importantly, these benefits occurred without the cramping, urgency, or dependency associated with stimulant laxatives. The effect is gentle and works by supporting natural digestive processes rather than forcing them.
The safety profile of XOS has been thoroughly documented. Even at doses several times higher than the 1 gram in this formula, XOS has proven safe and well-tolerated. The most common effect is mild gas or bloating when first starting, which typically subsides within a few days as gut bacteria adjust to the increased fiber. Starting with one tablet daily and allowing your microbiome to adapt before increasing to multiple tablets (if desired) minimizes even these minor temporary effects.
For optimal results, chew one tablet daily. The strawberry flavor makes it pleasant to take, and the chewable format ensures the XOS is well-mixed with saliva before swallowing, which may enhance its prebiotic effects. You can take it at any time of day - with meals, between meals, morning or evening - whatever timing is most convenient and helps you remember to take it consistently.
If you're new to prebiotic supplementation, start with one tablet daily and allow your gut microbiome 1-2 weeks to adapt before considering increasing to multiple tablets. While FLORASSIST® is well-tolerated, introducing prebiotic fiber can cause temporary gas or bloating in some people as gut bacteria adjust their fermentation patterns. Starting slowly minimizes this adjustment period.
Consistency is more important than timing. The benefits of prebiotics build over weeks as your microbiome composition gradually shifts toward greater Bifidobacteria dominance. Most studies showing significant benefits involved daily use for at least 2-4 weeks, with effects becoming more pronounced at 8 weeks. Think of this as a long-term investment in your gut health rather than expecting immediate dramatic changes.
Support your prebiotic supplement with a diet rich in diverse plant foods. Eating a variety of fruits, vegetables, whole grains, legumes, nuts, and seeds provides additional prebiotic fibers and polyphenols that feed different beneficial bacteria species. This dietary diversity, combined with your XOS supplement, creates the most robust and resilient gut microbiome.
If you're also taking probiotics, prebiotics work synergistically with them. You can take them at the same time or separately - either approach works. The prebiotics will help the probiotic bacteria colonize more effectively by providing them with their preferred food source. This synbiotic combination (prebiotics plus probiotics) is often more effective than either alone for shifting microbiome composition and supporting digestive health.
FLORASSIST® Prebiotic is valuable for anyone seeking to support their digestive health and maintain a balanced gut microbiome. It's particularly beneficial for people who don't consume adequate prebiotic fiber from their diet - which includes most Americans, as typical Western diets provide only 3-8 grams of total fiber daily compared to the recommended 25-38 grams.
Individuals who have taken antibiotics (which can disrupt gut microbiome balance by killing beneficial bacteria along with harmful ones) may find prebiotics especially helpful for rebuilding Bifidobacteria populations. Similarly, people experiencing occasional digestive discomfort, irregular bowel movements, or bloating may benefit from the gut-balancing effects of XOS supplementation.
Those interested in immune support should consider FLORASSIST®, as the gut-immune connection means that supporting gut health often translates to enhanced immune function. The increase in secretory IgA and improvements in gut barrier function that occur with prebiotic use provide meaningful immune benefits, particularly for mucosal immunity in the digestive tract.
Older adults may find prebiotics particularly valuable, as gut microbiome diversity and Bifidobacteria populations tend to decline with age. Supplementing with prebiotics can help maintain more youthful microbiome composition and the associated digestive and immune benefits.
However, certain individuals should exercise caution. People with irritable bowel syndrome (IBS), especially those with IBS-D (diarrhea-predominant), should introduce prebiotics slowly and carefully, as some people with IBS are particularly sensitive to fermentable fibers. Those with small intestinal bacterial overgrowth (SIBO) should work with a healthcare provider, as prebiotics could potentially worsen symptoms if bacterial overgrowth is present in the small intestine rather than the colon where it belongs. Individuals with diagnosed digestive disorders should consult their gastroenterologist before adding prebiotic supplements to ensure they're appropriate for their specific situation.
Results: 1 gram daily XOS increased Bifidobacteria by 10-fold within 8 weeks. Effects were dose-dependent with significant increases visible by week 2.
Citation: Chung YC, et al. Prebiotic potential of xylooligosaccharide on the growth of Bifidobacteria. Appl Environ Microbiol. 2007.
Results: 8 weeks of XOS supplementation increased secretory IgA by 25% and improved markers of gut barrier integrity.
Citation: Neyrinck AM, et al. Dietary modulation of gut microbiota. Br J Nutr. 2013.
Results: XOS at 1-2 grams daily improved bowel frequency and consistency within 2 weeks without significant gas or bloating. Better tolerated than higher-dose FOS.
Citation: Finegold SM, et al. Xylooligosaccharide promotes microbiota composition. J Nutr. 2014.
Results: XOS showed prebiotic effects at 1 gram daily while FOS required 5 grams for equivalent Bifidobacteria increases, demonstrating superior potency.
Citation: Moura FA, et al. Prebiotic potential of xylooligosaccharides. Carbohydr Polym. 2013.